Dai T Tran, FRACGP. Robert Salmon, FACD.
Potential photocarcinogenic effects of nanoparticle sunscreens
Article first published online: 16 AUG 2010
© 2010 The Authors. Australasian Journal of Dermatology © 2010 The Australasian College of Dermatologists
Australasian Journal of Dermatology
Volume 52, Issue 1, pages 1–6, February 2011
How to Cite
Tran, D. T. and Salmon, R. (2011), Potential photocarcinogenic effects of nanoparticle sunscreens. Australasian Journal of Dermatology, 52: 1–6. doi: 10.1111/j.1440-0960.2010.00677.x
- Issue published online: 21 FEB 2011
- Article first published online: 16 AUG 2010
- Submitted 3 March 2010; accepted 16 June 2010.
- barrier function;
- reactive oxygen species;
- titanium dioxide;
- zinc oxide
Titanium dioxide and zinc oxide nanoparticles are being increasingly formulated in sunscreens. While the same compounds, in larger particle form, work by reflecting UV radiation, in nanoparticle form, they absorb UV radiation, resulting in photocatalysis, releasing reactive oxygen species. These reactive oxygen species are known to have the capability to alter DNA. Previous studies suggest that this photocatalytic process may not be significant, because the nanoparticles do not penetrate below the level of the stratum corneum. However, some recent studies suggest that nanoparticles may, under certain circumstances, breach that barrier. The majority of those studies have used animal skin models rather than human skin.