Sarah Shen, BMedSci, MBBS. Tim O’Brien, FACD. Lei Mee Yap, FACD. H. Miles Prince, FRACP. Christopher J McCormack, FACD.
The use of methotrexate in dermatology: a review
Article first published online: 29 DEC 2011
© 2011 The Authors. Australasian Journal of Dermatology © 2011 The Australasian College of Dermatologists
Australasian Journal of Dermatology
Volume 53, Issue 1, pages 1–18, February 2012
How to Cite
Shen, S., O’Brien, T., Yap, L. M., Prince, H. M. and McCormack, C. J. (2012), The use of methotrexate in dermatology: a review. Australasian Journal of Dermatology, 53: 1–18. doi: 10.1111/j.1440-0960.2011.00839.x
- Issue published online: 6 FEB 2012
- Article first published online: 29 DEC 2011
- Submitted 17 September 2011; accepted 17 September 2011.
- adverse reactions;
- mechanism of action;
- treatment guidelines
Methotrexate is a synthetic folic acid analogue valued for both its anti-proliferative and anti-inflammatory properties. Considered one of the original immune-modifying agents, it is used widely for the treatment of steroid-recalcitrant inflammatory diseases. While there are abundant studies documenting its efficacy in rheumatic diseases, the use of methotrexate for dermatological conditions, with the exception of psoriasis, has yet to be comprehensively explored. This two-part review firstly outlines current data concerning the pharmacology of methotrexate, including its mechanism of action, side-effect profile and recommended therapeutic approach, and, secondly, examines the emerging evidence for methotrexate's efficacy in a wide range of cutaneous disorders.