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Warfarin-induced calciphylaxis successfully treated with sodium thiosulphate


  • Juber Hafiji, MB ChB, MRCP (UK). Patrick Deegan, MD MRCPI, FRCPath. Rebecca Brais, MRCPath. Paul Norris, MA, FRCP.

Dr Juber Hafiji, Skin Cancer Institute, Dermatological Surgical Unit, 171 Cameron Road, Tauranga 3152, New Zealand. Email:


Calciphylaxis is a rare life-threatening form of skin necrosis. Although traditionally observed in patients with end-stage renal disease and/or hyperparathyroidism, calciphylaxis has also been reported to occur in ‘non-traditional’ patients with normal renal and parathyroid function. We report a case of warfarin-induced calciphylaxis treated successfully with sodium thiosulphate and discuss the role of Vitamin K2 as a potential therapeutic option in the management of warfarin-induced calciphylaxis.

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