Role of paired Ig-like receptor-B in the humoral immune response
Version of Record online: 28 JUN 2008
Volume 53, Issue 2, pages 93–99, June 2004
How to Cite
Takai, T. (2004), Role of paired Ig-like receptor-B in the humoral immune response. Allergology International, 53: 93–99. doi: 10.1111/j.1440-1592.2004.00327.x
- Issue online: 28 JUN 2008
- Version of Record online: 28 JUN 2008
- Received 9 January 2003.
- B cell;
- dendritic cell;
- mast cell;
- Th2 response
The Ig-like receptors provide positive and negative regulation of immune cells upon recognition of various ligands, thus enabling those cells to respond adequately to extrinsic stimuli. Murine paired Ig-like receptor (PIR)-A and PIR-B, a typical receptor pair of the Ig-like receptor family, are expressed on a wide range of cells in the immune system, such as B cells, mast cells, macrophages and dendritic cells, mostly in a pair-wise fashion. The PIR-A requires the homodimeric Fc receptor common γ chain for its efficient cell-surface expression and for the delivery of activation signaling. In contrast, PIR-B inhibits receptor-mediated activation signaling in vitro upon engagement with other activating-type receptors, such as the antigen receptor on B cells and the high-affinity Fc receptor for IgE on mast cells. Although the ligands for PIR-A and PIR-B remain unknown, recent studies on PIR-B-deficient mice have provided us with valuable insight into the physiological significance of PIR-B, particularly in its regulatory role in balancing the humoral immune response.