Th1, Th2, Tc1 and Tc2 cells of patients with otolaryngological diseases


Dr Nobuo Ohta, Department of Otolaryngology, Yamagata University School of Medicine, 2-2-2 Iida-nishi, Yamagata-city, Yamagata 990-9585, Japan. Email:


Cytokines are important regulatory mediators secreted by T cells and other immunoactive cells. Based on the cytokine synthesis patterns, CD4 T cells can often be classified into at least two populations with different immune regulatory functions. The Th1 cells, producing interleukin (IL)-2 and interferon (IFN)-γ, are often associated with cell-mediated immune responses such as delayed type hypersensitivity (DTH), whereas Th2 cells, secreting IL-4, IL-5 and IL-13, usually provide B cell help and enhance allergic reactions. Naïve CD8 T cells, similar to CD4 T cells, can differentiate into at least two subsets of cytolytic effector cells with distinct cytokine patterns. The Tc1 cells secrete a Th1-like cytokine pattern, including IL-2 and IFN-γ. The Tc2 cells produce Th2 cytokines, including IL-4, IL-5 and Il-10. There is increasing evidence that Th1/Th2 and Tc1/Tc2 cytokine imbalance has been of pathogenetic importance in various diseases, such as allergic and autoimmune diseases. The present review article focuses on the evidence that the imbalance of Th1/Th2 and Tc1/Tc2 cytokines plays an important role in various otolaryngological diseases, such as Kimura's disease, Wegener's granulomatosism, acute perceptive hearing loss and Meniere's disease. It is concluded that the predominance of Th1 or Th2 and Tc1 or Tc2 cells may contribute to the mechanism in the pathogenesis of these otolaryngological diseases.