Human mast cell activation through Fc receptors and Toll-like receptors
Article first published online: 28 JUN 2008
Volume 53, Issue 3, pages 227–233, September 2004
How to Cite
Okayama, Y., Okumura, S., Tomita, H., Katayama, H., Yuki, K., Kagaya, S., Kashiwakura, J.-i. and Saito, H. (2004), Human mast cell activation through Fc receptors and Toll-like receptors. Allergology International, 53: 227–233. doi: 10.1111/j.1440-1592.2004.00338.x
- Issue published online: 28 JUN 2008
- Article first published online: 28 JUN 2008
- Received 26 December 2003.
- adaptive immunity;
- innate immunity;
- mast cell;
- Toll-like receptor 4
Mast cells express high-affinity IgE receptors (FcɛRI) on their surface and can be activated to secrete a variety of biologically active mediators by cross-linking of receptor-bound IgE. Recent studies in animal models indicate that mouse mast cells may play a protective role in host defense against bacteria through the production of tumor necrosis factor-α, mainly as a result of Toll-like receptor (TLR) 4- or CD48-mediated activation. Moreover, several recent observations in animal models have indicated that mast cells may also play a pivotal role in coordinating the early phases of autoimmune diseases, particularly those involving auto-antibodies. We recently identified functional TLR4 and FcγRI on human mast cells, in which their expression had been upregulated by interferon-γ. We compared each of the receptor-mediated gene expression profiles with the FcɛRI-mediated gene expression profile using high-density oligonucleotide probe arrays and discovered that human mast cells may modulate the immune system in a receptor-specific manner.