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Signal transducers and activators of transcription 6 (Stat6) variants in childhood and adult asthma

Authors


Dr Hirokazu Arakawa, Department of Pediatrics and Developmental Medicine, Gunma University Graduate School, Maebashi, Gunma 371-8511, Japan. Email: harakawa@showa.gunma-u.ac.jp

Abstract

Background:  Signal transducers and activators of transcription 6 (Stat6) is a key transcription factor involved in interleukin (IL)-4 and IL-13-mediated biological responses. Recently, we reported the association between the dinucleotide (GT) repeat polymorphism in the first exon of Stat6 and allergic subjects in a Japanese population. The aim of the present study was to evaluate whether this GT repeat polymorphism is associated with bronchial asthma, including childhood asthma and atopic and non-atopic adult asthma.

Methods: Stat6 gene polymorphisms were genotyped by polymerase chain reaction (PCR) fragment length polymorphism analysis.

Results:  In the first exon of Stat6, polymorphic PCR products were classified into six alleles (12−17 GT repeats). A significant difference was found in the genotypic frequency of the GT repeat polymorphism between controls and child asthmatics (P = 0.015), but not atopic or non-atopic adult asthma. The frequency of the 15 repeat allele (wild type) was lower in child asthmatics than in controls (P = 0.0047; odds ratio (OR) 1.6, 95% confidence interval (CI) 1.16−2.23), whereas shorter repeat alleles (12, 13 and 14 GT repeat) were higher in child asthmatics than in controls (P = 0.0064; OR (95%CI) 1.66 (1.15−2.39)).

Conclusion:  Genetic variations in the Stat6 gene may be associated with a predisposition for childhood asthma.

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