Clinical Institute of Neuroscience, Hospital Clínic, C/Villarroel 170, 08036 Barcelona, Spain. Email: email@example.com
Neuropsychological disturbances and cerebral blood flow in bipolar disorder
Article first published online: 18 MAR 2005
Australian and New Zealand Journal of Psychiatry
Volume 39, Issue 4, pages 227–234, April 2005
How to Cite
Benabarre, A., Vieta, E., Martínez-Arán, A., Garcia-Garcia, M., Martín, F., Lomeña, F., Torrent, C., Sánchez-Moreno, J., Colom, F., Reinares, M., Brugue, E. and Valdés, M. (2005), Neuropsychological disturbances and cerebral blood flow in bipolar disorder. Australian and New Zealand Journal of Psychiatry, 39: 227–234. doi: 10.1111/j.1440-1614.2004.01558.x
Antoni Benabarre, Psychiatrist; Anabel Martínez-Arán, Neuropsychologist; Carla Torrent, Psychologist; José Sánchez-Moreno, Research Assistant; Francesc Colom, Lecturer in Psychology; María Reinares, Research Assistant; Esteve Brugue, Resident in Psychiatry; Manuel Valdés, Professor and Head
Bipolar Disorders Program, Clinical Institute of Neuroscience, Hospital Clínic, IDIBAPS, Stanley Medical Research Center, University of Barcelona, Barcelona, Spain
Margarida Garcia-Garcia, Psychologist
Project Management Department, Biometrica, Barcelona, Spain
Francisco Martín, Neuroradiologist; Francisco Lomeña, Neuroradiologist
Department of Nuclear Medicine, Hospital Clinic, Barcelona, Spain
- Issue published online: 18 MAR 2005
- Article first published online: 18 MAR 2005
- Received 2 December 2004; accepted 12 December 2004.
- bipolar disorder;
Objective: To determine and correlate alterations in neuropsychological function and cerebral blood flow in bipolar patients.
Method: Assessments included the Positive and Negative Symptom Scale, Global Assessment Functioning, Wechsler Adult Intelligence Scale (WAIS), Wisconsin Card Sorting Test (WCST), Stroop test, Trail Making Test (TMT), California Verbal Learning Test (CVLT), Wechsler Memory Scale (WMS) and phonetic verbal fluency/controlled oral word association tests. Single photon emission computed tomography (SPECT) was carried out with the administration of 99mTc-HMPAO. Forty-three outpatients out of 85 fulfilling RDC diagnostic criteria for bipolar disorder and six healthy subjects were included in the study. SPECT and neuropsychological assessments were performed in 30 patients in manic (n = 7), hypomanic (n = 8), depressed (n = 12) or euthymic (n = 3) states. All assessments were carried out before starting treatment.
Result: Several corrected correlations between neuropsychological function and cerebral blood flow (CBF) were identified: executive function (WCST) and striatal, frontal, temporal, cerebellum, parietal and cingulate CBF; memory (WMS, WAIS-Digits) and striatal, frontal, temporal and parietal CBF; attentional tasks (Stroop) and striatal, temporo-medial and parietal CBF; verbal learning (CVLT) and frontal, posterior temporal, cingulate and occipital CBF; psychomotor disturbances (TMT) and anterior temporal CBF; poorer intelligence performance scores (WAIS-Vocabulary) and cerebellum and parietal CBF.
Conclusions: This study confirms the presence of functional disturbances in fronto-subcortical structures, the cerebellum and limbic system in bipolar patients.