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DIGITALIS RECEPTORS AND DIGOXIN SENSITIVITY IN RENAL FAILURE
Article first published online: 28 JUN 2007
DOI: 10.1111/j.1440-1681.1985.tb02313.x
Issue
1440-1681/asset/cover.gif?v=1&s=a348d8c520883138abe7615783701b4f4deccbe9 "Clinical and Experimental Pharmacology and Physiology")
Clinical and Experimental Pharmacology and Physiology
Volume 12, Issue 2, pages 115–120, April 1985
Additional Information
How to Cite
Malini, P. L., Strocchi, E., Feliciangeli, G., Buscaroli, A., Bonomini, V. and Ambrosioni, E. (1985), DIGITALIS RECEPTORS AND DIGOXIN SENSITIVITY IN RENAL FAILURE. Clinical and Experimental Pharmacology and Physiology, 12: 115–120. doi: 10.1111/j.1440-1681.1985.tb02313.x
Publication History
- Issue published online: 28 JUN 2007
- Article first published online: 28 JUN 2007
- Received 10 April 1984; revision received 11 August 1984
- Abstract
- References
- Cited By
Keywords:
- digitalis receptors;
- digoxin;
- erythrocytes;
- renal failure;
- 86rubidium.
SUMMARY
1. The number and the in vitro and in vivo affinity of digitalis receptors for digoxin were measured in patients with normal renal function and in uraemics.
2. In uraemic patients the number of receptors was decreased. Although their in vitro affinity for digoxin was unchanged the in vivo affinity was decreased, probably due to hyperkalaemia.
3. These findings provide a possible pharmacodynamic explanation for decreased activity of cardiac glycosides in chronic renal failure.