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INVESTIGATIONS INTO INTERACTIONS BETWEEN DOXAZOSIN AND ENALAPRILAT AT α1-ADRENOCEPTORS IN ANAESTHETIZED RATS
Article first published online: 28 JUN 2007
DOI: 10.1111/j.1440-1681.1991.tb01436.x
Issue
1440-1681/asset/cover.gif?v=1&s=a348d8c520883138abe7615783701b4f4deccbe9 "Clinical and Experimental Pharmacology and Physiology")
Clinical and Experimental Pharmacology and Physiology
Volume 18, Issue 4, pages 231–236, April 1991
Additional Information
How to Cite
Marwood, J., Tierney, G. and Stokes, G. (1991), INVESTIGATIONS INTO INTERACTIONS BETWEEN DOXAZOSIN AND ENALAPRILAT AT α1-ADRENOCEPTORS IN ANAESTHETIZED RATS. Clinical and Experimental Pharmacology and Physiology, 18: 231–236. doi: 10.1111/j.1440-1681.1991.tb01436.x
Publication History
- Issue published online: 28 JUN 2007
- Article first published online: 28 JUN 2007
- 7 January 1991
- Abstract
- References
- Cited By
Keywords:
- α1-adrenoceptor antagonists;
- ACE inhibitors;
- anaesthetized rats;
- doxazosin;
- enalaprilat;
- vascular α1-adrenoceptors
SUMMARY
1. In anaesthetized intact Sprague-Dawley rats, the angiotensin-converting enzyme inhibitor enalaprilat, 1 mg/kg, had no significant effect on the pressor responses to the α1-adrenoceptor agonist phenylephrine (PE). Doxazosin 1 mg/kg was found to be a potent α1-adrenoceptor antagonist.
2. The combination of enalaprilat 1 mg/kg plus doxazosin 1 mg/kg was 3.3-fold more potent in antagonizing α1-adrenoceptors than doxazosin 1 mg/kg alone.
3. After treatment of rats with deoxycorticosterone acetate (DOCA) twice weekly for 5 weeks, the α1-adrenoceptor antagonist action of doxazosin in anaesthetized rats was not potentiated by enalaprilat 1 mg/kg.
4. Since DOCA treatment suppresses renin activity, these findings strongly support the hypothesis that angiotensin II can modulate the functional activity of α1-adrenoceptor in vascular smooth muscle.