Effects of Hilsa ilisa fish oil on the atherogenic lipid profile and glycaemic status of streptozotocin-treated type 1 diabetic rats
Version of Record online: 2 FEB 2004
Clinical and Experimental Pharmacology and Physiology
Volume 31, Issue 1-2, pages 76–81, January 2004
How to Cite
Mahmud, I., Hossain, A., Hossain, S., Hannan, A., Ali, L. and Hashimoto, M. (2004), Effects of Hilsa ilisa fish oil on the atherogenic lipid profile and glycaemic status of streptozotocin-treated type 1 diabetic rats. Clinical and Experimental Pharmacology and Physiology, 31: 76–81. doi: 10.1111/j.1440-1681.2004.03953.x
- Issue online: 3 FEB 2004
- Version of Record online: 2 FEB 2004
- Received 7 May 2003; revision 2 September 2003; accepted 12 September 2003.
- Hilsa ilisa fish oil;
- lipid profile;
- platelet aggregation;
- total anti-oxidant status;
- type 1 diabetes
1. The effects of oral administration of Hilsa (Hilsa ilisa) fish oil (1 g oil/kg bodyweight per day) on the lipid profile, platelet aggregation, anti-oxidative status and glycaemic control of streptozotocin (STZ; 90 mg/kg bodyweight)-treated type 1 diabetic rats were compared with those in fish oil-treated or untreated non-diabetic rats.
2. After 3 weeks of fish oil feeding, plasma total cholesterol decreased in both the non-diabetic and diabetic rats by 35 and approximately 10%, respectively, and triglyceride fell by 69 and 20%, respectively, compared with control rats.
3. Fish oil feeding decreased non-esterified fatty acids (NEFA) by 29% in diabetic rats but the NEFA level in non-diabetic rats was unaffected.
4. In non-diabetic and diabetic rats, platelet aggregation decreased by 49 and 37%, respectively, and total anti-oxidant status increased by 18 and 17%, respectively, after fish oil feeding.
5. Insulin levels increased by 27% in the fish oil-fed non-diabetic rats, whereas insulin levels were markedly decreased in diabetic rats. Glucose levels were not altered at all and fructosamine levels decreased by 29% only in fish oil-fed diabetic rats.
6. The results of the present study suggest that Hilsa ilisa fish oil may ameliorate the atherogenic lipid profile, platelet hyperaggregation and the anti-oxidative defence of STZ-diabetic rats and the amelioration is thought to be independent of the effects of Hilsa on glycaemic control.