Presented at the AuPS (AHMRC) Symposium Environmental and Genetic Influences on Respiratory Health, November 2004. The papers in these proceedings were peer reviewed under the supervision of the AuPS editor. The papers are being published with the permission of AuPS and were initially published on the AuPS website http://www.aups.org.au
ENVIRONMENTAL FACTORS AND GENE–ENVIRONMENT INTERACTIONS IN THE AETIOLOGY OF ASTHMA
Article first published online: 14 FEB 2006
Clinical and Experimental Pharmacology and Physiology
Volume 33, Issue 3, pages 285–289, March 2006
How to Cite
Marks, G. B. (2006), ENVIRONMENTAL FACTORS AND GENE–ENVIRONMENT INTERACTIONS IN THE AETIOLOGY OF ASTHMA. Clinical and Experimental Pharmacology and Physiology, 33: 285–289. doi: 10.1111/j.1440-1681.2006.04360.x
- Issue published online: 14 FEB 2006
- Article first published online: 14 FEB 2006
- Received 28 October 2005; accepted 8 November 2005.
- CD14 genotype;
- house dust mite;
- hygiene hypothesis;
- toll-like receptor
- 1The importance of early life environmental influences on the aetiology of asthma is implied by the observed geographic and temporal variation in the prevalence of the disease among children.
- 2There is evidence pointing to the role of exposure to allergen, various aspects of diet and hygiene-related factors in the aetiology of asthma.
- 3There is also evidence that heritable factors influence the impact of hygiene-related exposures on the risk of having asthma. Polymorphism within genes coding for the toll-like receptor–lipopolysaccharide (TLR-LPS) signalling pathway may underlie variations in effects of hygiene-related exposures, including specifically endotoxin, on the risk of developing allergic sensitization and allergic disease.
- 4At present there is no unifying theory to explain the childhood origins of asthma and, hence, no solid basis for developing preventative interventions. Progress towards this goal requires better understanding of the heterogeneous nature of the disease in early childhood, improved characterization of relevant environmental exposures and long-term follow up of birth cohorts with reliable and valid measures of allergy and asthma outcomes.