Based on a presentation at The Biomedical Science Congress, 26–28 September 2005, Birmingham, UK.
POSSIBLE ANTIDIABETIC AND ANTIHYPERLIPIDAEMIC EFFECT OF FERMENTED PARKIA BIGLOBOSA (JACQ) EXTRACT IN ALLOXAN-INDUCED DIABETIC RATS§
Article first published online: 10 AUG 2006
Clinical and Experimental Pharmacology and Physiology
Volume 33, Issue 9, pages 808–812, September 2006
How to Cite
Odetola, A., Akinloye, O., Egunjobi, C., Adekunle, W. and Ayoola, A. (2006), POSSIBLE ANTIDIABETIC AND ANTIHYPERLIPIDAEMIC EFFECT OF FERMENTED PARKIA BIGLOBOSA (JACQ) EXTRACT IN ALLOXAN-INDUCED DIABETIC RATS. Clinical and Experimental Pharmacology and Physiology, 33: 808–812. doi: 10.1111/j.1440-1681.2006.04444.x
- Issue published online: 10 AUG 2006
- Article first published online: 10 AUG 2006
- Received 24 October 2005; revision 24 February 2006; accepted 6 March 2006.
- fasting plasma glucose;
- lipid profile;
- Parkia biglobosa
- 1The hypoglycaemic effect of fermented seeds of Parkia biglobosa (PB; African locust bean), a natural nutritional condiment that features frequently in some African diets as a spice, was investigated in the present study in alloxan-induced diabetic rats. Its effect was compared with that of glibenclamide (Daonil; Sanofi-Aventis, Paris, France), a reference antidiabetic drug. The effects of PB on lipid profiles were also examined.
- 2In order to assess the hypoglycaemic and hypolipidaemic effects of aqueous and methanolic extracts of PB on experimental animals, fasting plasma glucose (FPG), total cholesterol, triglyceride, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were determined. In addition, the weight of each animal was determined to assess any possible weight gain or loss in the experimental animals (diabetic rats treated with Daonil (group C), the aqueous extract of PB (group D) or the methanolic extract of PB (group E)) compared with control groups (non-diabetic (group A) and non-treated diabetic (group B)).
- 3A single dose of 120 mg/kg, i.v., alloxan administered to rats resulted in significant increases in the FPG (P < 0.001) of test animals compared with controls. However, dietary supplementation with PB (6 g/kg extract for 4 weeks administered orally using an intragastric tube) ameliorated the alloxan-induced diabetes in a manner comparable with that of the reference antidiabetic drug glibenclamide. Aqueous and methanolic extracts of PB (6% w/w) elicited 69.2% and 64.4% reductions, respectively, in FPG compared with 70.4% in 0.01 mg/150 g glibenclamide-treated rats.
- 4Although animals treated with the aqueous extract of PB gained weight in manner similar to normal controls, animals given the methanolic extract and glibenclamide lost weight in manner similar to non-treated diabetic rats. In addition, high levels of HDL and low LDL were observed in animals treated with the aqueous extract of PB, a pattern similar to that seen in normal controls. Low levels of HDL and high levels of LDL were observed in animals treated with the methanolic extract of PB, a pattern similar to that seen in non-treated diabetic controls.
- 5The results of the present study demonstrate that both aqueous and methanolic extracts of fermented seeds of PB exert a hypoglycaemic effect; hence, PB has an antidiabetic property. However, only the aqueous extract of PB ameliorated the loss of bodyweight usually associated with diabetes. Although the aqueous extract has a favourable lipid profile, which is probably an indication of its possible anti-arteriogenic property (hypertension and ischaemic heart diseases being common complications in diabetes mellitus), the methanolic extract shows possible contraindication to ischaemic heart diseases.