This paper has been peer reviewed.
ROLE OF REACTIVE METABOLITES OF OXYGEN AND NITROGEN IN PARTIAL LIVER TRANSPLANTATION: LESSONS LEARNED FROM REDUCED-SIZE LIVER ISCHAEMIA AND REPERFUSION INJURY
Article first published online: 26 APR 2007
Clinical and Experimental Pharmacology and Physiology
Volume 34, Issue 9, pages 912–919, September 2007
How to Cite
Urakami, H., Abe, Y. and Grisham, M. B. (2007), ROLE OF REACTIVE METABOLITES OF OXYGEN AND NITROGEN IN PARTIAL LIVER TRANSPLANTATION: LESSONS LEARNED FROM REDUCED-SIZE LIVER ISCHAEMIA AND REPERFUSION INJURY. Clinical and Experimental Pharmacology and Physiology, 34: 912–919. doi: 10.1111/j.1440-1681.2007.04640.x
- Issue published online: 26 APR 2007
- Article first published online: 26 APR 2007
- Received 25 May 2006; revised 16 January 2007; accepted 29 January 2007.
- liver transplantation;
- NADPH oxidase;
- nitric oxide;
- pro-inflammatory cytokines;
- reactive oxygen species
- 1Hepatic resection with concomitant periods of ischaemia and reperfusion (I/R) is required to perform reduced-size liver (RSL) transplantation procedures, such as living donor or split liver transplantation. Although a great deal of progress has been made using these types of surgical procedures, a significant number of patients develop tissue injury from these procedures, ultimately resulting in graft failure.
- 2Because of this, there is a real need to understand the different mechanisms responsible for the tissue injury induced by I/R of RSL transplantation (RSL + I/R), with the ultimate goal to develop new and improved therapeutic agents that may limit the tissue damage incurred during RSL transplantation.
- 3The present paper reviews the recent studies that have been performed examining the role of reactive metabolites of oxygen and nitrogen in a mouse model of RSL + I/R. In addition, we present data demonstrating how the pathophysiological mechanisms identified in this model compare with those observed in a model of RSL transplantation in rats.