ROLE OF REACTIVE METABOLITES OF OXYGEN AND NITROGEN IN PARTIAL LIVER TRANSPLANTATION: LESSONS LEARNED FROM REDUCED-SIZE LIVER ISCHAEMIA AND REPERFUSION INJURY

Authors


  • This paper has been peer reviewed.

Matthew B Grisham, Department of Molecular and Cellular Physiology, LSU Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA. Email: mgrish@lsuhsc.edu

SUMMARY

  • 1Hepatic resection with concomitant periods of ischaemia and reperfusion (I/R) is required to perform reduced-size liver (RSL) transplantation procedures, such as living donor or split liver transplantation. Although a great deal of progress has been made using these types of surgical procedures, a significant number of patients develop tissue injury from these procedures, ultimately resulting in graft failure.
  • 2Because of this, there is a real need to understand the different mechanisms responsible for the tissue injury induced by I/R of RSL transplantation (RSL + I/R), with the ultimate goal to develop new and improved therapeutic agents that may limit the tissue damage incurred during RSL transplantation.
  • 3The present paper reviews the recent studies that have been performed examining the role of reactive metabolites of oxygen and nitrogen in a mouse model of RSL + I/R. In addition, we present data demonstrating how the pathophysiological mechanisms identified in this model compare with those observed in a model of RSL transplantation in rats.

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