Presented at the AuPS Symposium Development and Physiological Adaptations of Neuronal Circuits and Synapses-I, September 2006. The papers in these proceedings were peer reviewed under the supervision of the AuPS Editor. The papers are being published with the permission of AuPS and were initially published on the AuPS website http://www.aups.org.au
FUNCTIONS OF SK CHANNELS IN CENTRAL NEURONS
Version of Record online: 15 AUG 2007
Clinical and Experimental Pharmacology and Physiology
Volume 34, Issue 10, pages 1077–1083, October 2007
How to Cite
Faber, E. L. and Sah, P. (2007), FUNCTIONS OF SK CHANNELS IN CENTRAL NEURONS. Clinical and Experimental Pharmacology and Physiology, 34: 1077–1083. doi: 10.1111/j.1440-1681.2007.04725.x
- Issue online: 15 AUG 2007
- Version of Record online: 15 AUG 2007
- Received 26 January 2007; revision 10 April 2007; accepted 25 April 2007.
- calcium activated potassium channels;
- synaptic plasticity;
- synaptic transmission
- 1SK channels are small-conductance calcium-activated potassium channels that are widely expressed in neurons. The traditional view of the functional role of SK channels is in mediating one component of the after-hyperpolarization that follows action potentials. Calcium influx via voltage-gated calcium channels active during action potentials opens SK channels and the resultant hyperpolarization lowers the firing frequency of action potentials in many neurons.
- 2Recent advances have shown that, in addition to controlling action potential firing frequency, SK channels are also important in regulating dendritic excitability, synaptic transmission and synaptic plasticity.
- 3In accordance with their role in modulating synaptic plasticity, SK channels are also important in regulating several learning and memory tasks and may also play a role in a number of neurological disorders.
- 4The present review discusses recent findings on the role of SK channels in central neurons.