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FUNCTIONAL DIVERSITY OF MAMMALIAN TYPE 2C PROTEIN PHOSPHATASE ISOFORMS: NEW TALES FROM AN OLD FAMILY
Article first published online: 9 JAN 2008
DOI: 10.1111/j.1440-1681.2007.04843.x
Issue
Clinical and Experimental Pharmacology and Physiology
Volume 35, Issue 2, pages 107–112, February 2008
Additional Information
How to Cite
Lu, G. and Wang, Y. (2008), FUNCTIONAL DIVERSITY OF MAMMALIAN TYPE 2C PROTEIN PHOSPHATASE ISOFORMS: NEW TALES FROM AN OLD FAMILY. Clinical and Experimental Pharmacology and Physiology, 35: 107–112. doi: 10.1111/j.1440-1681.2007.04843.x
Publication History
- Issue published online: 9 JAN 2008
- Article first published online: 9 JAN 2008
- Received 15 August 2007; revision 27 September 2007; accepted 27 September 2007.
- Abstract
- Article
- References
- Cited By
Keywords:
- human disease;
- protein phosphatase;
- signal transduction;
- Type 2C protein phosphatase (PP2C) isoforms
SUMMARY
- 1The Type 2C protein phosphatases (PP2C) represent a highly conserved gene family in the mammalian genome. Recent studies have revealed that PP2C isoforms possess unique patterns of tissue and subcellular distribution associated with diverse functionalities.
- 2The functional importance of PP2C isoforms has been shown in a plethora of signalling networks controlling cell differentiation, proliferation, growth, survival and metabolism. However, little is known about the regulatory mechanisms of PP2C at the molecular level. It is uncertain how PP2C isoforms are recruited, activated and inactivated during signalling transduction processes.
- 3In the present paper, an overview of the critical functions of individual PP2C isoforms in regulating cellular signalling events will be provided, along with our perspectives on the challenging issues to be addressed. It is clear that a better understanding of the complex biological effects elicited by specific signalling pathways involving PP2C isoforms has great potential for developing novel therapies for a variety of human diseases, including cancer, diabetes and neural disorders, as well as cardiovascular diseases.