Oral simvastatin reduces the hypertensive response to air-jet stress
Article first published online: 26 MAR 2012
© 2012 The Authors Clinical and Experimental Pharmacology and Physiology © 2012 Blackwell Publishing Asia Pty Ltd
Clinical and Experimental Pharmacology and Physiology
Volume 39, Issue 4, pages 350–356, April 2012
How to Cite
Ufnal, M., Drapala, A., Sikora, M. and Szczepanska-Sadowska, E. (2012), Oral simvastatin reduces the hypertensive response to air-jet stress. Clinical and Experimental Pharmacology and Physiology, 39: 350–356. doi: 10.1111/j.1440-1681.2012.05675.x
- Issue published online: 26 MAR 2012
- Article first published online: 26 MAR 2012
- Accepted manuscript online: 10 JAN 2012 12:19PM EST
- Manuscript Accepted: 4 JAN 2012
- Manuscript Revised: 30 DEC 2011
- Manuscript Received: 29 JUN 2011
- Medical University of Warsaw. Grant Number: 1MA/PM/12/11
- angiotensin II;
- blood pressure;
- Brain angiotensin (Ang) II and vasopressin play important roles in the neurogenic regulation of the circulatory system, such as in cardiovascular responses to stress. Recently, it has become evident that the positive effects of statins are not limited to their lipid-lowering actions; for example, it has been found that statins interact with angiotensin peptides.
- In the present study we tested the hypothesis that simvastatin affects haemodynamic responses to air-jet stress and intracerebroventricular infusions of vasopressin and AngII. We maintained 12-week-old male Sprague-Dawley rats either on tap water (control) or on water containing simvastatin (20, 40 or 60 mg/L) for 4 weeks. Subsequently, we measured arterial blood pressure and heart rate (HR) at baseline and after air-jet stress or intracerebroventricular infusions over 30 s of 10 ng AngII, 20 ng vasopressin or their antagonists (10 μg losartan and 400 ng d(CH2)5[Tyr(Me)2,Ala-NH29] vasopressin, respectively).
- There were no significant differences between the control and simvastatin groups in terms of baseline mean arterial blood pressure (MAP) and HR. In rats given 60 mg/L simvastatin, the hypertensive response to air-jet stress was significantly smaller than in controls, as was the increase in MAP in response to AngII. In contrast, there was no significant difference between the groups in terms of the hypertensive response to vasopressin.
- These findings show that simvastatin affects the hypertensive response to air-jet stress and provide evidence that statins may affect the brain's regulation of the circulatory system.