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Keywords:

  • cell differentiation;
  • crystallin;
  • enhancers;
  • PAX;
  • SOX;
  • transcription factor pair code

My group has long studied transcriptional gene regulation involved in cell differentiation, employing lens cell differentiation as a model. In this article, our progress over the last quarter of a century in deciphering the principles involved in developmental gene regulation is described, outlining concurrent advancement in relevant branches of developmental biology.