Mechanisms of trophectoderm fate specification in preimplantation mouse development
Article first published online: 20 JAN 2010
© 2010 The Author. Journal compilation © 2010 Japanese Society of Developmental Biologists
Development, Growth & Differentiation
Special Issue: Mammalian Stem Cells
Volume 52, Issue 3, pages 263–273, April 2010
How to Cite
Sasaki, H. (2010), Mechanisms of trophectoderm fate specification in preimplantation mouse development. Development, Growth & Differentiation, 52: 263–273. doi: 10.1111/j.1440-169X.2009.01158.x
- Issue published online: 28 MAR 2010
- Article first published online: 20 JAN 2010
- Received 4 November 2009; revised 24 November 2009; accepted 25 November 2009.
- Hippo signal;
During preimplantation mouse development, embryos establish two distinct cell lineages by the time of blastocyst formation: trophectoderm (TE) and inner cell mass (ICM). To explain the mechanism of this cell fate specification, two classical models, namely the inside–outside model and polarity model have been proposed based on experimental manipulation studies on embryos. This review summarizes recent findings on the molecular mechanisms of fate specification, and discusses how these findings fit into the classical models. TE development is regulated by a transcription factor cascade, the core transcription factors of which are Tead4 and Cdx2. The transcriptional activity of Tead4 is regulated by the position-dependent Hippo signaling pathway, thus supporting the inside–outside model. In contrast, several findings support the polarity model; some other findings suggest different mechanisms. We also discuss how the two classical models could be further developed in the light of recent molecular findings.