Embryonic and adult stem cell systems in mammals: Ontology and regulation
Article first published online: 11 JAN 2010
© 2010 The Authors. Journal compilation © 2010 Japanese Society of Developmental Biologists
Development, Growth & Differentiation
Special Issue: Comparative Aspects of Stem Cells
Volume 52, Issue 1, pages 115–129, January 2010
How to Cite
Katsumoto, K., Shiraki, N., Miki, R. and Kume, S. (2010), Embryonic and adult stem cell systems in mammals: Ontology and regulation. Development, Growth & Differentiation, 52: 115–129. doi: 10.1111/j.1440-169X.2009.01160.x
- Issue published online: 11 JAN 2010
- Article first published online: 11 JAN 2010
- Received 6 September 2009; revised 17 November 2009; accepted 20 November 2009.
- Embryonic stem cells;
- tissue stem cells
Stem cells are defined as having the ability to self-renew and to generate differentiated cells. During embryogenesis, cells are initially proliferative and pluripotent and then they gradually become restricted to different cell fates. In the adult, tissue stem cells are normally quiescent, but become proliferative upon injury. Knowledge from developmental biology and insights into the properties of stem cells are keys to further understanding and successful manipulation. Here, we first focus on ES cells, then on embryonic development, and then on tissue stem cells of endodermally derived tissues, particularly the liver and pancreas.