Epigenetic regulation in neural stem cell differentiation
Article first published online: 30 JUN 2010
© 2010 The Authors. Journal compilation © 2010 Japanese Society of Developmental Biologists
Development, Growth & Differentiation
Special Issue: Epigenetics
Volume 52, Issue 6, pages 493–504, August 2010
How to Cite
Juliandi, B., Abematsu, M. and Nakashima, K. (2010), Epigenetic regulation in neural stem cell differentiation. Development, Growth & Differentiation, 52: 493–504. doi: 10.1111/j.1440-169X.2010.01175.x
- Issue published online: 21 JUL 2010
- Article first published online: 30 JUN 2010
- Received 25 January 2010; revised 16 February 2010; accepted 17 February 2010.
- cell differentiation;
- neural stem cells
The central nervous system (CNS) is composed of three major cell types – neurons, astrocytes, and oligodendrocytes – which differentiate from common multipotent neural stem cells (NSCs). This differentiation process is regulated spatiotemporally during the course of mammalian development. It is becoming apparent that epigenetic regulation is an important cell-intrinsic program, which can interact with transcription factors and environmental cues to modulate the differentiation of NSCs. This knowledge is important given the potential of NSCs to produce specific CNS cell types that will be beneficial for clinical applications. Here we review recent findings that address molecular mechanisms of epigenetic and transcription factor-mediated regulation that specify NSC fate during CNS development, with a particular focus on the developing mammalian forebrain.