Role of cell death in the formation of sexual dimorphism in the Drosophila central nervous system
Article first published online: 22 FEB 2011
© 2011 The Author. Journal compilation © 2011 Japanese Society of Developmental Biologists
Development, Growth & Differentiation
Volume 53, Issue 2, pages 236–244, February 2011
How to Cite
Kimura, K.-I. (2011), Role of cell death in the formation of sexual dimorphism in the Drosophila central nervous system. Development, Growth & Differentiation, 53: 236–244. doi: 10.1111/j.1440-169X.2010.01223.x
- Issue published online: 22 FEB 2011
- Article first published online: 22 FEB 2011
- Received 27 August 2010; revised 16 September 2010; accepted 20 September 2010.
- courtship behavior;
- sexual dimorphism
Currently, sex differences in behavior are believed to result from sexually dimorphic neural circuits in the central nervous system (CNS). Drosophila melanogaster is a common model organism for studying the relationship between brain structure, behavior, and genes. Recent studies of sex-specific reproductive behaviors in D. melanogaster have addressed the contribution of sexual differences in the CNS to the control of sex-specific behaviors and the development of sexual dimorphism. For example, sexually dimorphic regions of the CNS are involved in the initiation of male courtship behavior, the generation of the courtship song, and the induction of male-specific muscles in D. melanogaster. In this review, I discuss recent findings about the contribution of cell death to the formation of sexually dimorphic neural circuitry and the regulation of sex-specific cell death by two sex determination factors, Fruitless and Doublesex, in Drosophila.