Present address: The Rockefeller University, 1230 York Avenue, New York, NY 10065.
Mitogenic signaling from apoptotic cells in Drosophila
Article first published online: 22 FEB 2011
© 2011 The Authors. Journal compilation © 2011 Japanese Society of Developmental Biologists
Development, Growth & Differentiation
Volume 53, Issue 2, pages 168–176, February 2011
How to Cite
Morata, G., Shlevkov, E. and Pérez-Garijo, A. (2011), Mitogenic signaling from apoptotic cells in Drosophila. Development, Growth & Differentiation, 53: 168–176. doi: 10.1111/j.1440-169X.2010.01225.x
- Issue published online: 22 FEB 2011
- Article first published online: 22 FEB 2011
- Received 30 August 2010; revised 16 September 2010; accepted 17 September 2010.
- decapentaplegic/wingless signaling;
- hyperplastic overgrowths;
- undead cells
Apoptotic cells of Drosophila not only activate caspases, but also are able to secrete developmental signals like Hedgehog (Hh), Decapentaplegic (Dpp) and Wingless (Wg) before dying. Since Dpp and Wg are secreted in growing tissues and behave as growth factors, it was proposed that they play a role in compensatory proliferation, the process by which a growing blastema can restore normal size after massive apoptosis. We discuss recent results showing that there is normal compensatory proliferation in the absence of Dpp/Wg signaling, thus indicating it has no significant role in the process. Furthermore, we argue that Dpp/Wg signaling is not a resident feature of apoptotic cells, but a side effect of the necessary activation of the JNK pathway. Nevertheless, the ectopic JNK/Dpp/Wg signaling may have an important role in tissue regeneration. Recent work in other organisms suggests that paracrine signaling from apoptotic cells may be of general significance in wound healing and tissue regeneration in metazoans.