Present address: Laboratory for Histogenetic Dynamics, RIKEN Center for Developmental Biology, Kobe 650-0047, Japan.
Caspase signaling in animal development
Article first published online: 22 FEB 2011
© 2011 The Author. Journal compilation © 2011 Japanese Society of Developmental Biologists
Development, Growth & Differentiation
Volume 53, Issue 2, pages 137–148, February 2011
How to Cite
Kuranaga, E. (2011), Caspase signaling in animal development. Development, Growth & Differentiation, 53: 137–148. doi: 10.1111/j.1440-169X.2010.01237.x
- Issue published online: 22 FEB 2011
- Article first published online: 22 FEB 2011
- Received 31 August 2010; revised 28 November 2010; accepted 28 November 2010.
- caspase signaling;
- cell differentiation;
- cell migration and shaping;
- cell proliferation
The caspases are a family of cysteine proteases that function as central regulators of cell death. Recent investigations in Caenorhabditis elegans, Drosophila, and mice indicate that caspases are essential not only in controlling the number of cells involved in sculpting or deleting structures in developing animals, but also in dynamic cell processes such as cell-fate determination, compensatory proliferation of neighboring cells, and actin cytoskeleton reorganization, in a non-apoptotic context during development. This review focuses primarily on caspase functions involving their enzymatic activity.