Regional expression of ADAM19 during chicken embryonic development

Authors

  • Xin Yan,

    1. Albrecht-Kossel-Institute for Neuroregeneration, School of Medicine University of Rostock, Gehlsheimer Strasse 20, D-18147 Rostock
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  • Juntang Lin,

    1. Institute of Anatomy I, School of Medicine University of Jena, Teichgraben 7, D-07743 Jena, Germany
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  • Annett Markus,

    1. Albrecht-Kossel-Institute for Neuroregeneration, School of Medicine University of Rostock, Gehlsheimer Strasse 20, D-18147 Rostock
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  • Arndt Rolfs,

    1. Albrecht-Kossel-Institute for Neuroregeneration, School of Medicine University of Rostock, Gehlsheimer Strasse 20, D-18147 Rostock
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  • Jiankai Luo

    Corresponding author
    1. Albrecht-Kossel-Institute for Neuroregeneration, School of Medicine University of Rostock, Gehlsheimer Strasse 20, D-18147 Rostock
      Author to whom all correspondence should be addressed.
      Email: jiankai.luo@uni-rostock.de
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Author to whom all correspondence should be addressed.
Email: jiankai.luo@uni-rostock.de

Abstract

ADAM19 (also named meltrin β) is a member of the ADAM (a disintegrin and metalloprotease) family of metalloproteases and is involved in morphogenesis and tissue formation during embryonic development. In the present study, chicken ADAM19 is cloned by reverse transcription–polymerase chain reaction and identified by sequencing. Its expression patterns in different parts of the developing chicken embryo are investigated by Western blot analysis and immunohistochemistry. Results show that ADAM19 protein is widely expressed in chicken embryos. It is detectable in the central nervous system, including the brain, spinal cord, cochlea, and retina. Furthermore, ADAM19 protein is also found in other tissues and organs such as digestive organs, the thymus, the lung bud, the dorsal aorta, the kidney, the gonad, muscles, and in the feather buds. All these data suggest that ADAM19 plays an important role in the embryonic development of chicken.

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