Repair responses to abnormalities in morphogen activity gradient
Article first published online: 22 FEB 2011
© 2011 The Authors. Journal compilation © 2011 Japanese Society of Developmental Biologists
Development, Growth & Differentiation
Volume 53, Issue 2, pages 161–167, February 2011
How to Cite
Takemura, M. and Adachi-Yamada, T. (2011), Repair responses to abnormalities in morphogen activity gradient. Development, Growth & Differentiation, 53: 161–167. doi: 10.1111/j.1440-169X.2011.01249.x
- Issue published online: 22 FEB 2011
- Article first published online: 22 FEB 2011
- Received 31 August 2010; revised 20 December 2010; accepted 21 December 2010.
Establishing and maintaining a morphogen gradient are important in the growth and patterning of developing organs. When a discontinuity in a morphogen signal gradient is created by somatic mutant clones with aberrant intensities of morphogen signals within the Drosophila wing disc, the clones can be removed by apoptosis to restore the morphogen signal gradient. This apoptosis is termed “morphogenetic apoptosis” and has been observed to occur in a cell autonomous or non-cell autonomous manner. This review discusses possible molecular mechanisms of both autonomous and non-cell autonomous apoptosis in addition to similar cellular events in reference to recent findings.