Present address: University Medical School of Geneva, Department of Physiology and Metabolism, Rue Michel Servet, CH-1211 Geneva.
Injury-induced activation of the MAPK/CREB pathway triggers apoptosis-induced compensatory proliferation in hydra head regeneration
Article first published online: 22 FEB 2011
© 2011 The Authors. Journal compilation © 2011 Japanese Society of Developmental Biologists
Development, Growth & Differentiation
Volume 53, Issue 2, pages 186–201, February 2011
How to Cite
Chera, S., Ghila, L., Wenger, Y. and Galliot, B. (2011), Injury-induced activation of the MAPK/CREB pathway triggers apoptosis-induced compensatory proliferation in hydra head regeneration. Development, Growth & Differentiation, 53: 186–201. doi: 10.1111/j.1440-169X.2011.01250.x
- Issue published online: 22 FEB 2011
- Article first published online: 22 FEB 2011
- Received 9 September 2010; revised 23 December 2010; accepted 24 December 2010.
Fig. S1. The HydraRSK gene.
Fig. S2. The HydraCBP gene.
Fig. S3. Characterization of the cellular alterations in head-regenerating halves at 1 hpa.
Fig. S4. Western blot analysis showing the RSK, CREB, CBP and actin protein levels in head-regenerating halves of hydra exposed 1x (A) or 3x (B) to dsRNAs.
Table S1. Modulations of CREB subcellular localisation in interstitial cells during early head regeneration.
Table S2. Inhibition of injury-induced apoptosis in RSK(RNAi), CREB(RNAi) or CBP(RNAi)Hydra (A) or in U0126-treated Hydra (B).
Table S3. Modulations in cell density and BrdU-labeling index in head-regenerating stumps after genetic or pharmacological inhibition of the MAPK/CREB pathway.
Table S4. Cell-type distribution among the BrdU positive cells found in the 3 regions of head-regenerating halves.
Table S5. Kinetics of head-regeneration in Hydra silenced for RSK, CREB or CBP.
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