Plasticity in the development and dedifferentiation of Dictyostelium discoideum
Article first published online: 18 MAY 2011
© 2011 The Authors. Development, Growth & Differentiation © 2011 Japanese Society of Developmental Biologists
Development, Growth & Differentiation
Special Issue: SOCIAL AMOEBA AND THE ORIGIN OF MULTICELLULARITY
Volume 53, Issue 4, pages 587–596, May 2011
How to Cite
Roberge-White, E. and Katoh-Kurasawa, M. (2011), Plasticity in the development and dedifferentiation of Dictyostelium discoideum. Development, Growth & Differentiation, 53: 587–596. doi: 10.1111/j.1440-169X.2011.01256.x
- Issue published online: 18 MAY 2011
- Article first published online: 18 MAY 2011
- Received 2 December 2010; revised 20 December 2010; accepted 26 December 2010.
- developmental commitment;
- erasure event;
Dictyostelium discoideum has served as a model for development and differentiation for over 70 years. Also regulated in Dictyostelium is the process of dedifferentiation, which consists of multiple cellular events that are separately regulated, providing an excellent model system for studying the return of partially differentiated cells to a more pluripotent state. An interesting aspect of Dictyostelium development is the plasticity between growth and development. Reversibility of the processes of differentiation and dedifferentiation exist, allowing Dictyostelium to adjust to changing conditions by reverting to the growth phase during differentiation or reinitiating development during dedifferentiation. This ability of cells to respond to environmental cues is mediated by the checkpoint-like events “commitment” and “erasure,” which occur during differentiation and dedifferentiation, respectively. Our review will discuss the current state of knowledge regarding dedifferentiation and the plasticity of the developmental process in both the forward and reverse directions.