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Keywords:

  • Dictyostelium;
  • PtdIns(3,4,5)P3;
  • phospholipase A2;
  • ras GTPase;
  • TorC2;
  • soluble guanylyl cyclase

Cells recognize external chemical gradients and translate these environmental cues into amplified intracellular signaling that results in elongated cell shape, actin polymerization toward the leading edge, and movement along the gradient. Mechanisms underlying chemotaxis are conserved evolutionarily from Dictyostelium amoeba to mammalian neutrophils. Recent studies have uncovered several parallel intracellular signaling pathways that crosstalk in chemotaxing cells. Here, we review these signaling mechanisms in Dictyostelium discoideum.