Signaling mechanisms for chemotaxis
Version of Record online: 18 MAY 2011
© 2011 The Authors. Development, Growth & Differentiation © 2011 Japanese Society of Developmental Biologists
Development, Growth & Differentiation
Special Issue: SOCIAL AMOEBA AND THE ORIGIN OF MULTICELLULARITY
Volume 53, Issue 4, pages 495–502, May 2011
How to Cite
Wang, Y., Chen, C.-L. and Iijima, M. (2011), Signaling mechanisms for chemotaxis. Development, Growth & Differentiation, 53: 495–502. doi: 10.1111/j.1440-169X.2011.01265.x
- Issue online: 18 MAY 2011
- Version of Record online: 18 MAY 2011
- Received 3 January 2011; revised 29 January 2011; accepted 1 February 2011.
- phospholipase A2;
- ras GTPase;
- soluble guanylyl cyclase
Cells recognize external chemical gradients and translate these environmental cues into amplified intracellular signaling that results in elongated cell shape, actin polymerization toward the leading edge, and movement along the gradient. Mechanisms underlying chemotaxis are conserved evolutionarily from Dictyostelium amoeba to mammalian neutrophils. Recent studies have uncovered several parallel intracellular signaling pathways that crosstalk in chemotaxing cells. Here, we review these signaling mechanisms in Dictyostelium discoideum.