Control of prestalk-cell differentiation by transcription factors
Article first published online: 18 MAY 2011
© 2011 The Author. Development, Growth & Differentiation © 2011 Japanese Society of Developmental Biologists
Development, Growth & Differentiation
Special Issue: SOCIAL AMOEBA AND THE ORIGIN OF MULTICELLULARITY
Volume 53, Issue 4, pages 538–547, May 2011
How to Cite
Fukuzawa, M. (2011), Control of prestalk-cell differentiation by transcription factors. Development, Growth & Differentiation, 53: 538–547. doi: 10.1111/j.1440-169X.2011.01269.x
- Issue published online: 18 MAY 2011
- Article first published online: 18 MAY 2011
- Received 21 January 2011; revised 2 February 2011; accepted 3 February 2011.
- differentiation inducing factor;
- prestalk cell;
- transcription factors
Transcriptional control of developmental genes is important for cell differentiation and pattern formation. Developing Dictyostelium discoideum cells form a multicellular structure in which individual cells differentiate into either stalk cells or spores. This simplicity makes the organism an attractive model for studying fundamental problems in developmental biology. However, the morphogenetic process of forming a stalked fruiting body conceals a certain degree of complexity. This is reflected in the presence of multiple prestalk subtypes that have individual roles to generate the fruiting body. This review describes recent advances in understanding the molecular mechanisms, mediated by transcription factors that generate prestalk-cell heterogeneity.