Present address: Department of Molecular Cell Biology, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyo-ku, Tokyo 113-8510, Japan.
Chemokine ligand Xenopus CXCLC (XCXCLC) regulates cell movements during early morphogenesis
Article first published online: 22 NOV 2011
© 2011 The Authors. Development, Growth & Differentiation © 2011 Japanese Society of Developmental Biologists
Development, Growth & Differentiation
Volume 53, Issue 9, pages 971–981, December 2011
How to Cite
Goto, T. and Asashima, M. (2011), Chemokine ligand Xenopus CXCLC (XCXCLC) regulates cell movements during early morphogenesis. Development, Growth & Differentiation, 53: 971–981. doi: 10.1111/j.1440-169X.2011.01304.x
- Issue published online: 14 DEC 2011
- Article first published online: 22 NOV 2011
- Received 8 June 2011; revised 15 September 2011; accepted 16 September 2011.
- cell attractant;
- chemokine ligand;
We cloned the gene for the CXC-type chemokine ligand, Xenopus CXCLC (XCXCLC), the transcripts of which were detected at the dorsal midline during the gastrula and neurula stages. XCXCLC overexpression resulted in the attraction of nearby mesodermal cells, and the excess of chemoattractant interfered with convergent and extension movements. The direction of the deep neural plate cells around the notoplate was also controlled by XCXCLC. Fluorescence signals for XCXCLC + enhanced green fluorescent protein derivatives accumulated around the notochord region. These results indicate that XCXCLC attracts adjacent cells to the midline region, so as to ensure accurate lateral-medial directional tissue convergence during gastrulation and neurulation.