Developmentally programmed, RNA-directed genome rearrangement in Tetrahymena
Version of Record online: 22 NOV 2011
© 2011 The Author. Development, Growth & Differentiation © 2011 Japanese Society of Developmental Biologists
Development, Growth & Differentiation
Special Issue: RNA and Development
Volume 54, Issue 1, pages 108–119, January 2012
How to Cite
Mochizuki, K. (2012), Developmentally programmed, RNA-directed genome rearrangement in Tetrahymena. Development, Growth & Differentiation, 54: 108–119. doi: 10.1111/j.1440-169X.2011.01305.x
- Issue online: 16 JAN 2012
- Version of Record online: 22 NOV 2011
- Received 16 August 2011; revised 18 September 2011; accepted 18 September 2011.
- Chromatin diminution;
- DNA elimination;
Developmentally programmed genome rearrangement has been observed in a variety of eukaryotes from vertebrates to worms to protists, and it provides an interesting exception to the general rule of the constancy of the genome. DNA elimination in the ciliated protozoan Tetrahymena is one of the most well-characterized programmed genome rearrangement events. DNA elimination in the newly formed macronucleus of Tetrahymena is epigenetically regulated by the DNA sequence of the parental macronucleus. Dicer-produced, Piwi-associated small RNAs mediate this epigenetic regulation, probably through a whole-genome comparison of the germline micronucleus to the somatic macronucleus. However, a correlation between small RNAs and programmed genome rearrangement could not be detected in the worm Ascaris suum. Therefore, different types of eukaryotes may have developed unique solutions to perform genome rearrangement.