Roles of cytoplasmic RNP granules in intracellular RNA localization and translational control in the Drosophila oocyte
Article first published online: 24 NOV 2011
© 2011 The Authors. Development, Growth & Differentiation © 2011 Japanese Society of Developmental Biologists
Development, Growth & Differentiation
Special Issue: RNA and Development
Volume 54, Issue 1, pages 19–31, January 2012
How to Cite
Kato, Y. and Nakamura, A. (2012), Roles of cytoplasmic RNP granules in intracellular RNA localization and translational control in the Drosophila oocyte. Development, Growth & Differentiation, 54: 19–31. doi: 10.1111/j.1440-169X.2011.01314.x
- Issue published online: 16 JAN 2012
- Article first published online: 24 NOV 2011
- Received 27 August 2011; revised 19 October 2011; accepted 19 October 2011.
- mRNA localization;
- P body;
- translational control
Intracellular mRNA localization and translation are ways to achieve asymmetric protein sorting in polarized cells, and they play fundamental roles in cell-fate decisions and body patterning during animal development. These processes are regulated by the interplay between cis-acting elements and trans-acting RNA-binding proteins that form and occur within a ribonucleoprotein (RNP) complex. Recent studies in the Drosophila oocyte have revealed that RNP complex assembly in the nucleus is critical for the regulation of cytoplasmic mRNA localization and translation. Furthermore, several trans-acting factors promote the reorganization of target mRNAs in the cytoplasm into higher-order RNP granules, which are often visible by light microscopy. Therefore, RNA localization and translation are likely to be coupled within these RNP granules. Notably, diverse cytoplasmic RNP granules observed in different cell types share conserved sets of proteins, suggesting they have fundamental and common cellular functions.