Neuronal subtype specification in the cerebellum and dorsal hindbrain
Article first published online: 8 MAR 2012
© 2012 The Author. Development, Growth & Differentiation © 2012 Japanese Society of Developmental Biologists
Development, Growth & Differentiation
Special Issue: Neural Development Edited by T. Miyata.
Volume 54, Issue 3, pages 317–326, April 2012
How to Cite
Hoshino, M. (2012), Neuronal subtype specification in the cerebellum and dorsal hindbrain. Development, Growth & Differentiation, 54: 317–326. doi: 10.1111/j.1440-169X.2012.01330.x
- Issue published online: 24 APR 2012
- Article first published online: 8 MAR 2012
- Received 27 December 2011; revised 19 January 2012; accepted 20 January 2012.
- cochlear nucelus;
- precerebellar system;
- subtype specification
In the nervous system, there are hundreds to thousands of neuronal cell types that have morphologically, physiologically, and histochemically different characteristics and this diversity may enable us to elicit higher brain function. A better understanding of the molecular machinery by which neuron subtype specification occurs is thus one of the most important issues in brain science. The dorsal hindbrain, including the cerebellum, is a good model system to study this issue because a variety of types of neurons are produced from this region. Recently developed genetic lineage-tracing methods in addition to gene-transfer technologies have clarified a fate map of neurons produced from the dorsal hindbrain and accelerated our understanding of the molecular machinery of neuronal subtype specification in the nervous system.