Positional information in neural map development: Lessons from the olfactory system
Article first published online: 8 MAR 2012
© 2012 The Author. Development, Growth & Differentiation © 2012 Japanese Society of Developmental Biologists
Development, Growth & Differentiation
Special Issue: Neural Development Edited by T. Miyata.
Volume 54, Issue 3, pages 358–365, April 2012
How to Cite
Imai, T. (2012), Positional information in neural map development: Lessons from the olfactory system. Development, Growth & Differentiation, 54: 358–365. doi: 10.1111/j.1440-169X.2012.01334.x
- Issue published online: 24 APR 2012
- Article first published online: 8 MAR 2012
- Received 28 November 2011; revised 12 January 2012; accepted 28 January 2012.
- axon sorting;
- neural map;
- odorant receptor;
- positional information
Positional information is fundamental in development. Although molecular gradients are thought to represent positional information in various systems, the molecular logic used to interpret these gradients remains controversial. In the nervous system, sensory maps are formed in the brain based on gradients of axon guidance molecules. However, it remains unclear how axons find their targets based on relative, not absolute, expression levels of axon guidance receptors. No model solely based on axon–target interactions explains this point. Recent studies in the olfactory system suggested that the neural map formation requires axon–axon interactions, which is known as axon sorting. This review discusses how axon–axon and axon–target interactions interpret molecular gradients and determine the axonal projection sites in neural map formation.