These authors contributed equally to this study.
Small leucine rich proteoglycan family regulates multiple signalling pathways in neural development and maintenance
Article first published online: 24 APR 2012
© 2012 The Authors Development, Growth & Differentiation © 2012 Japanese Society of Developmental Biologists
Development, Growth & Differentiation
Special Issue: Neural Development Edited by T. Miyata.
Volume 54, Issue 3, pages 327–340, April 2012
How to Cite
Dellett, M., Hu, W., Papadaki, V. and Ohnuma, S.-i. (2012), Small leucine rich proteoglycan family regulates multiple signalling pathways in neural development and maintenance. Development, Growth & Differentiation, 54: 327–340. doi: 10.1111/j.1440-169X.2012.01339.x
- Issue published online: 24 APR 2012
- Article first published online: 24 APR 2012
- Manuscript Accepted: 7 FEB 2012
- Manuscript Received: 1 FEB 2012
- Fight for Sight studentship
- British Retinitis Pigmentosa Society
- extracellular matrix;
- neural development;
- small leucine rich proteoglycan family;
The small leucine-rich repeat proteoglycan (SLRPs) family of proteins currently consists of five classes, based on their structural composition and chromosomal location. As biologically active components of the extracellular matrix (ECM), SLRPs were known to bind to various collagens, having a role in regulating fibril assembly, organization and degradation. More recently, as a function of their diverse proteins cores and glycosaminoglycan side chains, SLRPs have been shown to be able to bind various cell surface receptors, growth factors, cytokines and other ECM components resulting in the ability to influence various cellular functions. Their involvement in several signaling pathways such as Wnt, transforming growth factor-β and epidermal growth factor receptor also highlights their role as matricellular proteins. SLRP family members are expressed during neural development and in adult neural tissues, including ocular tissues. This review focuses on describing SLRP family members involvement in neural development with a brief summary of their role in non-neural ocular tissues and in response to neural injury.