Control of asymmetric cell division of mammalian neural progenitors
Version of Record online: 24 APR 2012
© 2012 The Authors Development, Growth & Differentiation © 2012 Japanese Society of Developmental Biologists
Development, Growth & Differentiation
Special Issue: Neural Development Edited by T. Miyata.
Volume 54, Issue 3, pages 277–286, April 2012
How to Cite
Shitamukai, A. and Matsuzaki, F. (2012), Control of asymmetric cell division of mammalian neural progenitors. Development, Growth & Differentiation, 54: 277–286. doi: 10.1111/j.1440-169X.2012.01345.x
- Issue online: 24 APR 2012
- Version of Record online: 24 APR 2012
- Manuscript Accepted: 28 FEB 2012
- Manuscript Received: 14 FEB 2012
- asymmetric cell division;
- epithelial structure;
- radial glial cells
Although the vertebrate brain commonly stems from the neuroepithelial tube, the size and complexity of the pseudostratified organization of the brain have drastically expanded during mammalian evolution, resulting in the formation of a highly folded cortex. Developmental controls of neural progenitor divisions underlie these events. In this review, we introduce recent progress in understanding the control of proliferation and differentiation of neural progenitors from a structural point of view. We particularly shed light on the roles of epithelial structure and mitotic spindle orientation in the generation of various types of neural progenitors.