How does Fgf signaling from the isthmic organizer induce midbrain and cerebellum development?
Version of Record online: 6 JAN 2005
Development, Growth & Differentiation
Volume 46, Issue 6, pages 487–494, December 2004
How to Cite
Sato, T., Joyner, A. L. and Nakamura, H. (2004), How does Fgf signaling from the isthmic organizer induce midbrain and cerebellum development?. Development, Growth & Differentiation, 46: 487–494. doi: 10.1111/j.1440-169x.2004.00769.x
- Issue online: 6 JAN 2005
- Version of Record online: 6 JAN 2005
- Received 31 July 2004; revised 13 October 2004; accepted 21 October 2004.
- 1992. Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis. Genes Dev. 6, 1589–1607. , , et al.
- 2000. The transcription factor Lmx1b maintains Wnt1 expression within the isthmic organizer. Development 127, 1857–1867. , , ,
- 1984. Homotopic and heterotopic transplantations of quail tectal primordia in chick embryos: organization of the retinotectal projections in the chimeric embryos. Dev Biol. 103, 378–398.DOI: 10.1016/0012-1606(84)90326-9 &
- 1992. Relationship between Wnt-1 and En-2 expression domains during early development of normal and ectopic met-mesencephalon. Development 115, 999–1009. , , ,
- 1999. The caudal limit of Otx2 expression positions the isthmic organizer. Nature 401, 164–168.DOI: 10.1038/43670 , ,
- 1993. Pax: gene regulators in the developing nervous system. J. Neurobiol. 24, 1367–1384. , , , ,
- 2003. The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum. Development 130, 2633–2644. , , ,
- 1999. Spatial response to fibroblast growth factor signalling in Xenopus embryos. Development 126, 119–125. &
- 2003. Spatial and temporal patterns of ERK signaling during mouse embryogenesis. Development 130, 4527–4537. , , ,
- 1995. The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. Development 121, 439–451. &
- 1996. Midbrain development induced by FGF8 in the chick embryo. Nature 380, 66–68. , ,
- 1988. Expression patterns of the homeo box-containing genes En-1 and En-2 and the proto-oncogene int-1 diverge during mouse development. Genes Dev. 2, 1736–1744. &
- 1999. A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer. Nature 401, 161–164.DOI: 10.1038/43664 , , , , ,
- 1998. Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo. Mech. Dev. 74, 175–177.DOI: 10.1016/S0925-4773(98)00061-6 , , , , ,
- 1999. Role of Pax5 in the regulation of a mid-hindbrain organizerís activity. Dev. Growth Differ. 41, 59–72.DOI: 10.1046/j.1440-169x.1999.00401.x , , , , ,
- 1997. In situ activation pattern of Drosophila EGF receptor pathway during development. Science 277, 1103–1106.DOI: 10.1126/science.277.5329.1103 , ,
- 1991. The cellular environment controls the expression of engrailed-like protein in the cranial neuroepithelium of quail/chick-chimeric embryos. Development 113, 1037–1048. &
- 1992. Pax in development. Cell 69, 719–722. &
- 1995. Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2. Science 269, 679–682. , , , ,
- 1999. Fgf8 and Gbx2 induction concomitant with Otx2 repression is correlated with midbrain-hindbrain fate of caudal prosencephalon. Development 126, 3191–3203. , ,
- 1999. Regeneration of isthmic tissue is the result of a specific and direct interaction between rhombomere 1 and midbrain. Development 126, 3981–3989. &
- 2003. Isthmus-to-midbrain transformation in the absence of midbrain-hindbrain organizer activity. Development 130, 6611–6623.DOI: 10.1242/dev.00899 , , , ,
- 1996. Engrailed, Wnt and Pax genes regulate midbrain – hindbrain development. Trends Genet. 12, 15–20.DOI: 10.1016/0168-9525(96)81383-7
- 1985. Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene. Cell 43, 29–37. , , , ,
- 2000. Otx2, Gbx2 and Fgf8 interact to position and maintain a mid-hindbrain organizer. Curr. Opin. Cell Biol. 12, 736–741.DOI: 10.1016/S0955-0674(00)00161-7 , ,
- 1987. En-1 and En-2, two mouse genes with sequence homology to the Drosophila engrailed gene: expression during embryogenesis. Genes Dev. 1, 29–38. &
- 2000. Interaction between Otx2 and Gbx2 defines the organizer center for the optic tectum. Mech. Dev. 91, 43–52.DOI: 10.1016/S0925-4773(99)00262-2 , , et al.
- 1997. Signal transduction from multiple Ras effectors. Curr. Opin. Genet. Dev. 7, 75–79.DOI: 10.1016/S0959-437X(97)80112-8 &
- 2003. The Iroquois homeobox gene Irx2 is not essential for normal development of the heart and midbrain–hindbrain boundary in mice. Mol. Cell Biol. 23, 8216–8225.DOI: 10.1128/MCB.23.22.8216-8225.2003 , , et al.
- 1997. Evidence that FGF8 signaling from the midbrain-hindbrain junction regulates growth and polarity in the developing midbrain. Development 124, 959–969. , , ,
- 2001. Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression. Development 128, 4979–4991. &
- 2002. Changing requirements for Gbx2 in development of the cerebellum and maintenace of the mid/hindbrain organizer. Neuron 36, 31–43.DOI: 10.1016/S0896-6273(02)00935-2 , ,
- 2001a. Early anterior/posterior patterning of the midbrain and cerebellum. Annu. Rev. Neurosci. 24, 869–896.DOI: 10.1146/annurev.neuro.24.1.869 &
- 2001b. EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain region. Development 128, 181–191. &
- 2003. FGF17 and FGF18 have different midbrain regulatory properties from FGF8b or activated FGF receptors. Development 130, 6175–6185.DOI: 10.1242/dev.00845 , , , , ,
- 1999. FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate. Development 126, 4827–4838. , ,
- 2002. Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18. Genes Dev. 16, 859–869.DOI: 10.1101/gad.965602 , , ,
- 1995a. FGF-8 isoforms differ in NIH3T3 cell transforming potential. Cell Growth Differ. 6, 817–825. , , , ,
- 1999. FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression. Development 126, 1189–1200. , , , ,
- 1995. Induction of ectopic engrailed expression and fate change in avian rhombomeres: intersegmental boundaries as barriers. Mech. Dev. 51, 289–303.DOI: 10.1016/0925-4773(95)00376-2 , , ,
- 1991. Induction of a mesencephalic phenotype in the 2-day-old chick prosencephalon is preceded by the early expression of the homeobox gene en. Neuron 6, 971–981.DOI: 10.1016/0896-6273(91)90237-T , ,
- 2001. Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2. Development 128, 4789–4800. , , et al.
- 2004. The prepattern transcription factor Irx2, a target of the FGF8/MAP kinase cascade, is involved in cerebellum formation. Nat. Neurosci. 7, 605–612.DOI: 10.1038/nn1249 , , et al.
- 2002. Role of Lmx1b and Wnt1 in mesencephalon and metencephalon development. Development 129, 5269–5277. , ,
- 1990. The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell 62, 1073–1085. &
- 1998. An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Nature Genet. 18, 136–141.DOI: 10.1038/ng0298-136 , ,
- 1996. The caudal limit of Otx2 gene expression as a marker of the midbrain/hindbrain boundary: a study using in situ hybridisation and chick/quail homotopic grafts. Development 122, 3785–3797. , , ,
- 1990. Do CNS anlagen have plasticity in differentiation? Analysis in quail-chick chimera. Brain Res. 511, 122–128.DOI: 10.1016/0006-8993(90)90231-Y
- 2001a. Regionalization of the optic tectum: combinations of gene expression that define the tectum. Trends Neurosci. 24, 32–39.DOI: 10.1016/S0166-2236(00)01676-3
- 2001b. Regionalisation and polarity formation of the optic tectum. Prog. Neurobiol. 65, 473–488.DOI: 10.1016/S0301-0082(01)00015-6
- 1992. Expression of en in the prosencephalon heterotopically transplanted into the mesencephalon. Dev. Growth Differ. 34, 387–391. &
- 1986. Plasticity and rigidity of differentiation of brain vesicles studied in quail-chick chimeras. Cell Differ. 19, 187–193.DOI: 10.1016/0045-6039(86)90095-3 , , , ,
- 2002. FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis. Genes Dev. 16, 870–879.DOI: 10.1101/gad.965702 , , et al.
- 2000. Involvement of fibroblast growth factor (FGF) 18-FGF8 signaling in specification of left-right asymmetry and brain and limb development of the chick embryo. Mech. Dev. 95, 55–66.DOI: 10.1016/S0925-4773(00)00331-2 , , ,
- 1998. Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain–hindbrain boundary development and somitogenesis. Development 125, 2381–2395. , , , , ,
- 2001. The midbrain – hindbrain boundary organizer. Curr. Opin. Neurobiol. 11, 34–42.DOI: 10.1016/S0959-4388(00)00171-9 &
- 1998. Ras-a versatile cellular switch. Curr. Opin. Genet. Dev. 8, 412–418.DOI: 10.1016/S0959-437X(98)80111-1 &
- 1995. Pax-2 expression in the murine neural plate precedes and encompasses the expression domains of Wnt-1 and En-1. Mech Dev. 52, 3–8.DOI: 10.1016/0925-4773(95)00380-J &
- 2001. Inductive signal and tissue responsiveness defining the tectum and the cerebellum. Development 128, 2461–2469. , ,
- 2004. The Fgf8 signal causes cerebellar differentiation by activating Ras-ERK signaling pathway. Development 131, 4275–4285.DOI: 10.1242/dev.01281 &
- 1997. Conserved biological function between Pax2 and Pax5 in midbrain and cerebellum development: evidence from targeted mutations. Proc. Natl. Acad. Sci. USA 94, 14518–14523.DOI: 10.1073/pnas.94.26.14518 , , , ,
- 1999. Sequential roles for Fgf4, En1 and Fgf8 in specification and regionalisation of the midbrain. Development 126, 945–959. , , , , ,
- 2001. Fgf signalling through MAPK cascade is required for development of the subpallial telencephalon in zebrafish embryos. Development 128, 4153–4164. , , , ,
- 2000. Positioning the isthmic organizer where Otx2 and Gbx2 meet. Trends Genet. 16, 237–240.DOI: 10.1016/S0168-9525(00)02000-X
- 2001. FgFr3 and regionalization of anterior neural tube in zebrafish. Mech. Dev. 102, 213–17.DOI: 10.1016/S0925-4773(01)00280-5 , , , , ,
- Two Pax-binding sites are required for early embryonic brain expression of an Engrailed-2 transgene. Development 122, 627–635. , , ,
- 2000. Antagonizing activity of chick Grg4 against tectum-organizing activity. Dev. Biol. 221, 168–180.DOI: 10.1006/dbio.2000.9643 , ,
- 1990. Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature 346, 847–850.DOI: 10.1038/346847a0 &
- 2003. FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals. EMBO J. 22, 1811–1823.DOI: 10.1093/emboj/cdg169 , , et al.
- 2000. Expression of FGFR1, FGFR2 and FGFR3 during early neural development in the chick embryo. Mech. Dev. 90, 103–110.DOI: 10.1016/S0925-4773(99)00225-7 &
- 1997. Specification of the anterior hindbrain, establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function. Development 124, 2923–2934. , , et al.
- 1999. The role of the rhmbic lip in avian cerebellum development. Development 126, 4395–4404. &
- 2001. Neural plate patterning: upstream and downstream of the isthmic organizer. Nat. Rev. Neurosci. 2, 99–108.DOI: 10.1038/35053516 &
- 1999. Genomic structure, mapping, activity and expression of fibroblast growth factor 17. Mech. Dev. 83, 165–178.DOI: 10.1016/S0925-4773(99)00034-9 , , ,
- 2000. Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures. Development 127, 1833–1843. , ,
- 2001. Distinct regulators control the expression of the mid-hindbrain organizer signal FGF8. Nature Neurosci. 4, 1175–1181.DOI: 10.1038/nn761 , , , et al.
- 2004. Cell behavior and genetic lineages of the mesencephalon and rhombomere1. Neuron 43, 345–357.DOI: 10.1016/j.neuron.2004.07.010 , , ,