Fission-track (FT) and (U–Th–Sm)/He (He) analyses are used to constrain the denudation pattern and history of the Kiso Range, a Japanese fault-block mountain range which has been uplifted since ca 0.8 Ma. We obtained nine zircon FT ages ranging 59.3–42.1 Ma, 18 apatite FT ages ranging 81.9–2.3 Ma, and 13 apatite He ages ranging 36.7–2.2 Ma. The apatite FT and He ages are divided into an older group comparable to the zircon FT age range and a younger group of <18 Ma. The younger ages are interpreted as a reflection of uplift of the Kiso Range because they were obtained only to the east of the Seinaiji-touge Fault, and the event age estimated from apatite FT data is consistent with the timing of the onset of the Kiso Range uplift. On the basis of the distribution of the younger ages, we propose westward tilting uplift of the Kiso Range between the boundary fault of the Inadani Fault Zone and Seinaiji-touge Fault, which implies a model of bedrock uplift that is intermediate between two existing models: a pop-up model in which the Kiso Range is squeezed upward between the two faults and a tilted uplift model which assumes that the Kiso Range is uplifted and tilted to the west by the Inadani Fault Zone. The original land surface before the onset of uplift/denudation of the Kiso Range is estimated to have been uplifted to an elevation of 2700–4900 m. We estimated denudation rates at 1.3–4.0 mm/y and maximum bedrock uplift rates at 3.4–6.1 mm/y since ca 0.8 Ma. The Seinaiji-touge fault is interpreted as a back thrust of the west-dipping Inadani Fault Zone. The older group of apatite FT and He ages is interpreted to reflect long-term peneplanation with a probable denudation rate of <0.1 mm/y.