MB, BS (HK), MRCP (UK); Registrar.
Synergism of chronic alcoholism and hepatitis B infection in liver disease
Article first published online: 10 MAR 2008
Journal of Gastroenterology and Hepatology
Volume 4, Issue 1, pages 11–16, February 1989
How to Cite
CHUNG, H.-T., LAI, C.-L., WU, P.-C. and LOK, A. S. F. (1989), Synergism of chronic alcoholism and hepatitis B infection in liver disease. Journal of Gastroenterology and Hepatology, 4: 11–16. doi: 10.1111/j.1440-1746.1989.tb00801.x
- Issue published online: 10 MAR 2008
- Article first published online: 10 MAR 2008
- Accepted for publication 6 July 1988
- alcoholic liver disease;
- hepatitis B infection;
One hundred and fifty-seven patients with alcoholic liver disease were studied. Hepatitis B surface antigen (HBsAg) was positive in 20.4% of the patients. Those who were positive for the HBsAg presented at an earlier age, had a lower albumin level, a higher globulin level, a more prolonged prothrombin time, were more likely to have features of cirrhosis in the liver biopsy, and were probably more likely to suffer from hepatic encephalopathy in the follow-up compared with those negative for HBsAg. The mortality of subjects was low both on admission and during follow-up. It is concluded that chronic alcoholism and hepatitis B virus infection act synergistically in producing more severe liver damage and causing cirrhosis at a younger age compared with chronic alcoholism alone. One possible reason for the low mortality of the patients might have been their relatively good nutritional status.