*Sponsored by the Ministry of Health and Welfare. Principal participant institutions: Iwate Medical School, University of Tokyo, Chiba University, Showa University, Tokyo Women's Medical College, Tokyo Medico-Dental School, Kitasato University, Juntendo University, Kanazawa University, Osaka City University, Okayama University, Ehime University, Yamaguchi University, Kurume University, Kagoshima University, Gifu University and Gifu Prefecture Hospital.
Aetiology and prognosis of fulminant viral hepatitis in Japan: A multicentre study
Article first published online: 10 MAR 2008
Journal of Gastroenterology and Hepatology
Volume 6, Issue 2, pages 159–164, April 1991
How to Cite
TAKAHASHI, Y., SHIMIZU, M. and THE STUDY GROUP OF FULMINANT HEPATITIS (1991), Aetiology and prognosis of fulminant viral hepatitis in Japan: A multicentre study. Journal of Gastroenterology and Hepatology, 6: 159–164. doi: 10.1111/j.1440-1746.1991.tb01458.x
- Issue published online: 10 MAR 2008
- Article first published online: 10 MAR 2008
- Accepted for publication 10 September 1990.
- blood transfusion, aetiology, fulminant hepatitis
In 236 patients with fulminant viral hepatitis (FVH), type B (FBH) was most common (47.5%), followed by non-A non-B hepatitis (FNANB, 44.9%) and hepatitis type A (FAH, 7.6%). The survival rate was significantly higher in the FAH group than in the FBH and FNANB groups (61.1, 36.6 and 18.9% respectively), and was significantly higher in the FBH group than in the FNANB group. In spite of screening for hepatitis B virus (HBV), FBH was prevalent (27 of 41) in post-transfusion cases; this phenomenon is discussed in relation to a recently revealed mutation of HBV. Within a month after the onset of hepatitis symptoms all cases in the FAH, 93% in the FBH and 79% in the FNANB group, developed encephalopathy. When the duration of illness before the onset of encephalopathy was more than 10 days (a subacute form), the survival rate was significantly lower than when encephalopathy developed in less than 11 days (an acute form). This difference could be accounted for by the difference in the relative frequency of aetiological viruses in the two forms and the higher survival rate in the acute, than the subacute, form in the FNANB group.