Effect of α-interferon on hepatitis B virus-specific cytotoxic T cells
Article first published online: 28 JUN 2008
Journal of Gastroenterology and Hepatology
Volume 10, Issue 1, pages 24–29, February 1995
How to Cite
ISONO, E., YAMAUCHI, K., HARUTA, I., KAMOGAWA, Y. and HAYASHI, N. (1995), Effect of α-interferon on hepatitis B virus-specific cytotoxic T cells. Journal of Gastroenterology and Hepatology, 10: 24–29. doi: 10.1111/j.1440-1746.1995.tb01042.x
- Issue published online: 28 JUN 2008
- Article first published online: 28 JUN 2008
- Accepted for publication 5 June 1994.
- cytotoxic T cell;
- hepatitis B virus.
Abstract To study the mechanism of the effects of α-interferon (α-IFN) on chronic hepatitis B, we examined its effect on hepatitis B virus (HBV)-specific cytotoxic T cells (CTL). Using two different HBV-DNA transfected human myeloma cell lines, one expressing hepatitis B core antigen (HBcAg; C4) and the other expressing hepatitis B surface antigen (HBsAg; S6) as targets in cytotoxic tests in vitro, peripheral blood mononuclear cells obtained from chronic hepatitis B patients who were treated with α-IFN were examined for their cytotoxic activity against these transfectants. During the treatment with α-IFN, in association with a decline of serum alanine amino transferase levels, CTL activities were significantly reduced. An inhibition study in vitro revealed that α-IFN did not directly inhibit these CTL activities, indicating that α-IFN may inhibit the induction of CTL, and thereby may be related to the reduction of hepatocyte injury.