1440-1746/asset/cover.gif?v=1&s=21c855b1ae39a2b6adb45c61684c395c28c53e57 "Journal of Gastroenterology and Hepatology")
The authors are indebted to Christiane Bertin and Christine Dauvergne for their expert technical assistance.
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Relationship between hepatic blood flow, liver tests, haemodynamic values and clinical characteristics in patients with chronic liver disease†
Article first published online: 28 JUN 2008
DOI: 10.1111/j.1440-1746.1997.tb00401.x
Additional Information
How to Cite
GADANO, A., HADENGUE, A., VACHIERY, F., MOREAU, R., SOGNI, P., SOUPISON, T., YANG, S., CAILMAIL, S. and LEBREC, D. (1997), Relationship between hepatic blood flow, liver tests, haemodynamic values and clinical characteristics in patients with chronic liver disease. Journal of Gastroenterology and Hepatology, 12: 167–171. doi: 10.1111/j.1440-1746.1997.tb00401.x
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*This work was presented in part at the 28th Annual Meeting of the European Association for the Study of the Liver (1-4 September 1993, Paris, France) and was published in an abstract form (J. Hepatol. 1993; 18 (Suppl. 1): S38).
Publication History
- Issue published online: 28 JUN 2008
- Article first published online: 28 JUN 2008
- Accepted for publication 5 July 1996.
- Abstract
- References
- Cited By
Keywords:
- cirrhosis;
- hepatic blood flow;
- portal hypertension.
ABSTRACT
Although hepatic blood flow (HBF) has been measured in patients with liver disease for many years, the results of these studies have not provided clear information concerning the usefulness of this measurement. Hepatic blood flow was measured in 392 patients with either cirrhosis (n= 356) or hepatic fibrosis (n= 36). The control group included 59 subjects with normal liver architecture. Hepatic clearance of indocyanine green (ICG) was markedly reduced in patients with cirrhosis and hepatic fibrosis compared with controls (182±5, 276±22 and 421±25 mL/min, respectively). In patients with cirrhosis, ICG clearance and extraction were significantly correlated, but were not correlated to HBF. Although HBF did not differ between patients with cirrhosis and controls (1.26±0.04 vs 1.35±0.07 L/min, respectively), patients with hepatic fibrosis had lower HBF (1.04±0.07 L/min; P< 0.05). In patients with cirrhosis, no correlation was observed between HBF and cardiac output, mean arterial pressure, azygos blood flow, the hepatic venous pressure gradient or Pugh's score. However, a significant difference in HBF was observed in patients with and without hepatic encephalopathy (1.00±0.09 vs 1.28±0.03 L/min, respectively; P<0.05). In conclusion, the present study shows that, in patients with cirrhosis, HBF is normal and is not related to other haemodynamic values or liver tests. These results discourage the measurement of HBF in the evaluation of patients with cirrhosis.