High viral load is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis B virus infection
Article first published online: 18 MAY 2004
Journal of Gastroenterology and Hepatology
Volume 19, Issue 6, pages 670–675, June 2004
How to Cite
OHATA, K., HAMASAKI, K., TORIYAMA, K., ISHIKAWA, H., NAKAO, K. and EGUCHI, K. (2004), High viral load is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis B virus infection. Journal of Gastroenterology and Hepatology, 19: 670–675. doi: 10.1111/j.1440-1746.2004.03360.x
- Issue published online: 18 MAY 2004
- Article first published online: 18 MAY 2004
- Accepted for publication 26 September 2003.
- hepatitis B virus;
- hepatitis B virus DNA;
- hepatocellular carcinoma;
- risk factor
Background and Aims: Hepatitis B virus (HBV) is considered a major risk factor for the progression to liver cirrhosis and hepatocellular carcinoma (HCC). The serum level of HBV-DNA is correlated with progression of the disease. The aim of the present study was to determine the relationship between the level of HBV-DNA and hepatocarcinogenesis in patients with chronic HBV infection.
Methods: The authors studied 73 patients who were diagnosed with chronic HBV infection at Nagasaki University Hospital (Nagasaki, Japan) between January 1980 and December 1999. The significance of age, sex, habitual drinking, serum alanine aminotransferase level, HBV viral load, interferon treatment, hepatic fibrosis and hepatic inflammation on the development of HCC were examined using univariate and multivariate analyses.
Results: The cumulative incidence rates of HCC were 14%, 29% and 48% at 5, 10 and 15 years after liver biopsy, respectively. Multivariate analysis identified high viral load, together with age and severe fibrosis, as independent and significant risk factors (P = 0.045, 0.047 and 0.013, respectively) for HCC.
Conclusions: The present findings indicate that high viral load is a risk factor for HCC in patients with chronic HBV infection. Patients with a high HBV viral load should be carefully monitored for HCC.