Alterations in cerebral potentials evoked by rectal distention and drinking ice water in patients with irritable bowel syndrome
Article first published online: 16 AUG 2006
Journal of Gastroenterology and Hepatology
Volume 21, Issue 12, pages 1844–1849, December 2006
How to Cite
Zuo, X. L., Li, Y. Q., Huang, K. M., Kuang, R. G., Lv, G. P., Lu, X. F., Li, J. M. and Desmond, P. V. (2006), Alterations in cerebral potentials evoked by rectal distention and drinking ice water in patients with irritable bowel syndrome. Journal of Gastroenterology and Hepatology, 21: 1844–1849. doi: 10.1111/j.1440-1746.2006.04176.x
- Issue published online: 27 OCT 2006
- Article first published online: 16 AUG 2006
- Accepted for publication 22 July 2005.
- cerebral evoked potentials;
- ice water;
- irritable bowel syndrome;
- rectal distention;
- visceral hypersensitivity
Aim: Visceral hypersensitivity has been found to be present in irritable bowel syndrome (IBS). The current study sought to study visceral afferent hypersensitivity in IBS patients and obtain further objective evidence of alterations in intestinal afferent pathways in IBS patients by cerebral evoked potentials (CEP).
Method: We studied 30 female IBS patients and 12 female healthy subjects. Rectal perception thresholds to balloon distention were measured and CEP was recorded in response to rhythmic rectal distention (two distention series, each of 100 repetitions at a frequency of 1 Hz) at the volume of perception thresholds. All subjects were then asked to drink 220 mL 4°C ice water and the above steps were repeated 20 min later.
Results: Rectal distention led to recognizable and reproducible CEP. Compared to healthy subjects, IBS patients demonstrated significantly shorter N1, P1 and N2 latencies (P < 0.05). After drinking ice water, IBS patients exhibited further shortened N1, P1 and N2 latencies (P < 0.05), but drinking did not alter the latencies of healthy controls and the amplitudes of both IBS patients and healthy controls.
Conclusion: The shorter latency of cerebral potentials evoked by rectal distention and ice water stimulation in IBS patients provided further objective evidence for defective visceral afferent transmission in IBS patients.