Comparison of liver histopathology between chronic hepatitis C patients and chronic hepatitis B and C-coinfected patients
Article first published online: 26 JUL 2006
Journal of Gastroenterology and Hepatology
Volume 22, Issue 4, pages 515–517, April 2007
How to Cite
Lee, L.-P., Dai, C.-Y., Chuang, W.-L., Chang, W.-Y., Hou, N.-J., Hsieh, M.-Y., Lin, Z.-Y., Chen, S.-C., Hsieh, M.-Y., Wang, L.-Y., Chen, T.-J. and Yu, M.-L. (2007), Comparison of liver histopathology between chronic hepatitis C patients and chronic hepatitis B and C-coinfected patients. Journal of Gastroenterology and Hepatology, 22: 515–517. doi: 10.1111/j.1440-1746.2006.04547.x
- Issue published online: 20 MAR 2007
- Article first published online: 26 JUL 2006
- Accepted for publication 22 March 2006.
- chronic hepatitis;
Background: The aim of the present study was to compare the histological characteristics of livers between chronic hepatitis C (CHC) patients with and without hepatitis B virus (HBV) coinfection.
Methods: A total of 336 CHC patients (male/female: 204/132, mean age: 46.1 ± 11.7 years) were enrolled in the study; 32 patients (9.8%) were positive for hepatitis B surface antigen (HBsAg). The histological characteristics of livers were described according to the Knodell and Scheuer scoring system.
Results: The proportion of non-intralobular necrosis (score 0) was significantly lower and the mean intralobular necrosis score was higher among CHC patients with HBV coinfection than those without coinfection (43.8% vs 64.5%; 0.84 ± 1.05 vs 0.53 ± 0.89). The epidemiological and virological parameters, and other histological scores (periportal necrosis, portal inflammation, total necroinflammation and fibrosis) were not significantly different between these two groups.
Conclusion: Chronic hepatitis C patients with HBV coinfection tend to have more severe intralobular necrosis than those with isolated HCV infection.