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Comparison of liver histopathology between chronic hepatitis C patients and chronic hepatitis B and C-coinfected patients

Authors

  • Li-Po Lee,

    1. Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Chung-Ho Memorial Hospital,
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  • Chia-Yen Dai,

    1. Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Chung-Ho Memorial Hospital,
    2. Gastroenterological Division, Faculty of Internal Medicine, College of Medicine, Kaohsiung Medical University,
    3. Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, and
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  • Wan-Long Chuang,

    1. Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Chung-Ho Memorial Hospital,
    2. Gastroenterological Division, Faculty of Internal Medicine, College of Medicine, Kaohsiung Medical University,
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  • Wen-Yu Chang,

    1. Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Chung-Ho Memorial Hospital,
    2. Gastroenterological Division, Faculty of Internal Medicine, College of Medicine, Kaohsiung Medical University,
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  • Nei-Jen Hou,

    1. Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, and
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  • Ming-Yen Hsieh,

    1. Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Chung-Ho Memorial Hospital,
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  • Zu-Yau Lin,

    1. Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Chung-Ho Memorial Hospital,
    2. Gastroenterological Division, Faculty of Internal Medicine, College of Medicine, Kaohsiung Medical University,
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  • Shinn-Cherng Chen,

    1. Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Chung-Ho Memorial Hospital,
    2. Gastroenterological Division, Faculty of Internal Medicine, College of Medicine, Kaohsiung Medical University,
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  • Ming-Yuh Hsieh,

    1. Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Chung-Ho Memorial Hospital,
    2. Gastroenterological Division, Faculty of Internal Medicine, College of Medicine, Kaohsiung Medical University,
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  • Liang-Yen Wang,

    1. Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Chung-Ho Memorial Hospital,
    2. Gastroenterological Division, Faculty of Internal Medicine, College of Medicine, Kaohsiung Medical University,
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  • Tong-Jong Chen,

    1. Department of Pathology and Laboratory Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan
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  • Ming-Lung Yu

    Corresponding author
    1. Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Chung-Ho Memorial Hospital,
    2. Gastroenterological Division, Faculty of Internal Medicine, College of Medicine, Kaohsiung Medical University,
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Dr Ming-Lung Yu, Hepatobiliary Division, Department of Internal Medicine, Kaohsiung, Medical University Hospital, no. 100 Tzyou 1st Road, Kaohsiung 807, Taiwan. Email: fishya@ms14.hinet.net

Abstract

Background:  The aim of the present study was to compare the histological characteristics of livers between chronic hepatitis C (CHC) patients with and without hepatitis B virus (HBV) coinfection.

Methods:  A total of 336 CHC patients (male/female: 204/132, mean age: 46.1 ± 11.7 years) were enrolled in the study; 32 patients (9.8%) were positive for hepatitis B surface antigen (HBsAg). The histological characteristics of livers were described according to the Knodell and Scheuer scoring system.

Results:  The proportion of non-intralobular necrosis (score 0) was significantly lower and the mean intralobular necrosis score was higher among CHC patients with HBV coinfection than those without coinfection (43.8% vs 64.5%; 0.84 ± 1.05 vs 0.53 ± 0.89). The epidemiological and virological parameters, and other histological scores (periportal necrosis, portal inflammation, total necroinflammation and fibrosis) were not significantly different between these two groups.

Conclusion:  Chronic hepatitis C patients with HBV coinfection tend to have more severe intralobular necrosis than those with isolated HCV infection.

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