Cell death in pancreatitis: Effects of alcohol

Authors

  • Anna S Gukovskaya,

    1. Veterans Affairs Greater Los Angeles Healthcare System and Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, USC-UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Los Angeles, California, USA
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  • Olga A Mareninova,

    1. Veterans Affairs Greater Los Angeles Healthcare System and Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, USC-UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Los Angeles, California, USA
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  • Irina V Odinokova,

    1. Veterans Affairs Greater Los Angeles Healthcare System and Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, USC-UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Los Angeles, California, USA
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  • Kai-Feng Sung,

    1. Veterans Affairs Greater Los Angeles Healthcare System and Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, USC-UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Los Angeles, California, USA
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  • Aurelia Lugea,

    1. Veterans Affairs Greater Los Angeles Healthcare System and Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, USC-UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Los Angeles, California, USA
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  • Lars Fischer,

    1. Veterans Affairs Greater Los Angeles Healthcare System and Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, USC-UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Los Angeles, California, USA
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  • Yan-Ling Wang,

    1. Veterans Affairs Greater Los Angeles Healthcare System and Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, USC-UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Los Angeles, California, USA
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  • Ilya Gukovsky,

    1. Veterans Affairs Greater Los Angeles Healthcare System and Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, USC-UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Los Angeles, California, USA
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  • Stephen J Pandol

    1. Veterans Affairs Greater Los Angeles Healthcare System and Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, USC-UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Los Angeles, California, USA
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Anna S Gukovskaya, VAGLAHS, West Los Angeles VA Healthcare Center, 11301 Wilshire Boulevard, Building 258, Room 340, Los Angeles, CA 90073, USA.
Email: agukovsk@ucla.edu

Abstract

Pancreatitis is a severe and frequently lethal disorder, a major cause of which is alcohol abuse. Parenchymal cell death is a major complication of pancreatitis. In experimental models of (non-alcoholic) acute pancreatitis, acinar cells have been shown to die through both necrosis and apoptosis, the two principal pathways of cell death. The severity of experimental acute pancreatitis correlates directly with the extent of necrosis and inversely with apoptosis. Thus, understanding the regulation of apoptosis and necrosis, and whether it is possible to manipulate the pattern of death responses, is becoming exceedingly important in investigations of the pathogenesis and treatment of pancreatitis. The effects of alcohol on cell death responses of pancreatitis, and the mechanisms that may mediate these effects, are just starting to be explored. This paper reviews the signaling pathways mediating the balance between apoptosis and necrosis in acute pancreatitis, and alcohol’s effects on cell death responses in pancreatitis.

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