Evaluation of the role of nuclear factor-κB signaling in liver injury using genetic animal models


Christian Trautwein, Medizinische Klinik III, University Hospital, RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.
Email: ctrautwein@ukaachen.de


Most chronic liver diseases are not sufficiently treatable at present and very often progress to liver fibrosis and liver cirrhosis. Several recent studies have suggested that cytokines and cytokine-activated inflammatory signaling pathways might play an important role in the mediation of liver injury. Although pro-inflammatory signaling pathways such as nuclear factor (NF)-κB have evolved primarily for host defense to infections, they appear to be involved in the pathogenesis of inflammatory diseases and may mediate liver injury in response to a variety of agents and pathogens. Herein is summarized briefly some recent findings concerning the role of NF-κB in different models of liver injury based on transgenic and knockout animal technology.