• 1
    Kang JY, Tay HH, Yap I, Guan R, Lim KP, Math MV. Low frequency of endoscopic esophagitis in Asian patients. J. Clin. Gastroenterol. 1993; 16: 703.
  • 2
    Goh KL, Chang SC, Fock KM, Ke MY, Park HJ, Lam SK. Gastro-oesophageal reflux disease in Asia. J. Gastroenterol. Hepatol. 2000; 15: 2308.
  • 3
    Goh K. Changing epidemiology of gastroesophageal reflux disease in the Asian-Pacific region: an overview. J. Gastroenterol. Hepatol. 2004; 19: S225.
  • 4
    Lim LG, Ho KY. Gastroesophageal reflux disease at the turn of millennium. World J. Gastroenterol. 2003; 9: 21356.
  • 5
    Fujimoto K. Review article: prevalence and epidemiology of gastro-oesophageal reflux disease in Japan. Aliment. Pharmacol. Ther. 2004; 20 (Suppl. 8): 58.
  • 6
    Fock KM, Talley N, Hunt R et al. Report of the Asia-Pacific consensus on the management of gastroesophageal reflux disease. J. Gastroenterol. Hepatol. 2004; 19: 35767.
  • 7
    Inamori M, Togawa J, Nagase H et al. Clinical characteristics of Japanese reflux esophagitis patients as determined by Los Angeles classification. J. Gastroenterol. Hepatol. 2003; 18:1726.
  • 8
    Okamoto K, Iwakiri R, Mori M. Clinical symptoms in endoscopic reflux esophagitis: evaluation in 8031 adult subjects. Dig. Dis. Sci. 2003; 48: 223741.
  • 9
    Rosaida MS, Goh KL. Gastro-oesophageal reflux disease, reflux oesophagitis and non-erosive reflux disease in a multiracial Asian population: a prospective, endoscopy based study. Eur. J. Gastroenterol. Hepatol. 2004; 16: 495501.
  • 10
    Wai CT, Yeoh KG, Ho KY, Kang JY, Lim SG. Diagnostic yield of upper endoscopy in Asian patients presenting with dyspepsia. Gastrointest. Endosc. 2002; 56: 54851.
  • 11
    Rajendra S, Kutty K, Karim N. Ethnic differences in the prevalence of endoscopic esophagitis and Barrett's esophagus: the long and short of it all. Dig. Dis. Sci. 2004; 49: 23742.
  • 12
    Pan GZ, Xu GM, Ke MY et al. Epidemiological study of symptomatic gastro esophageal reflux disease in China: Beijing and Shanghai. Chin. J. Dig. Dis. 2000; 1: 28.
  • 13
    Wong WM, Lai KC, Lam KF et al. Prevalence, clinical spectrum and health care utilization of gastro-oesophageal reflux disease in a Chinese population: a population-based study. Aliment. Pharmacol. Ther. 2003; 18: 595604.
  • 14
    Rajendra S, Alahuddin S. Racial differences in the prevalence of heartburn. Aliment. Pharmacol. Ther. 2004; 19: 375.
  • 15
    Fujiwara Y, Higuchi K, Watanabe Y et al. Prevalence of gastroesophageal reflux disease and gastroesophageal reflux disease symptoms in Japan. J. Gastroenterol. Hepatol. 2005; 20: 269.
  • 16
    Wang JH, Luo JY, Dong L, Gong J, Tong M. Epidemiology of gastroesophageal reflux disease: a general population-based study in Xian of Northwest China. World J. Gastroenterol. 2004; 10: 164751.
  • 17
    Lim SL, Goh WT, Lee JM et al. Changing prevalence of gastroesophageal reflux with changing time: longitudinal study in an Asian population. J. Gastroenterol. Hepatol. 2005; 20: 9951001.
  • 18
    Ho KY, Chan YH, Kang JY. Increasing trend of reflux esophagitis and decreasing trend of Helicobacter pylori infection in patients from a multiethnic Asian country. Am. J. Gastroenterol. 2005; 100: 19238.
    Direct Link:
  • 19
    Sollano JD, Wong SN, Andal-Gamutan T et al.. Erosive esophagitis in the Philippines: A comparison between two time periods. J. Gastroenterol. Hepatol. 2007; 22: 16505.
  • 20
    Wong SN, Sollano JD, Chan MM et al. Changing trends in peptic ulcer prevalence in a tertiary care setting in the Philippines: a seven-year study. J. Gastroenterol. Hepatol. 2005; 20: 62832.
  • 21
    Kang MS, Park DI, Oh SY et al. Abdominnal obesity is an independent risk factor for erosive esophagitis in a Korean population. J. Gastroenterol. Hepatol. 2007; 22: 165661.
  • 22
    Wong WM, Lam KF, Lai KC et al. A validated symptoms questionnaire Chinese GERDQ for the diagnosis of gastro-oesophageal reflux disease in the Chinese population. Aliment. Pharmacol. Ther. 2003; 17: 140713.
  • 23
    World Health Organization. Obesity: Preventing and Managing the Global Epidemic, Technical Report Series No. 894. WHO, 2000; 1253.
  • 24
    WHO/ISAO/IOTF. The Asia-Pacific Perspective: Redefining Obesity and its Treatment 2002. Cited 21 Feb 2007. Available from URL:
  • 25
    Gu D, Reynolds K, Wu X et al. Prevalence of the metabolic syndrome and overweight among adults in China. Lancet 2005; 365: 1398405.
  • 26
    Wu Y. Overweight and obesity in China. The once lean giant has a weight problem that is increasing rapidly. BMJ 2006; 333: 3623.
  • 27
    Chitturi S, Farrell GC, George J. Non-alcoholic steatohepatitis in the Asia-Pacific region: future shock? [Review]. J. Gastroenterol. Hepatol. 2004; 19: 36874.
  • 28
    Li G, Chen X, Jang Y et al. Obesity, coronary heart disease risk factors and diabetes in Chinese: an approach to the criteria of obesity in the Chinese population. Obes. Rev. 2002; 3: 16772.
  • 29
    Ishikawa-Takata K, Ohta T, Moritaki K, Gotou T, Inoue S. Obesity, weight change and risks for hypertension, diabetes and hypercholesterolemia in Japanese men. Eur. J. Clin. Nutr. 2002; 56: 6017.
  • 30
    Barak N, Ehrenpreis ED, Harrison JR, Sitrin MD. Gastro-oesophageal reflux disease in obesity: pathophysiological and therapeutic considerations. Obes. Rev. 2002; 3: 915.
  • 31
    Maddox A, Horowitz M, Wishart J, Collins P. Gastric and oesophageal emptying in obesity. Scand. J. Gastroenterol. 1989; 24: 5938.
  • 32
    O'Brien TF Jr. Lower esophageal sphincter pressure (LESP) and esophageal function in obese humans. J. Clin. Gastroenterol. 1980; 2: 1458.
  • 33
    Orlando RC. Overview of the mechanisms of gastroesophageal reflux. Am. J. Med. 2001; 111 (Suppl. 8A): 174S7S.
  • 34
    Pandolfino JE, El-Serag HB, Zhang Q, Shah N, Ghosh SK, Kahrilas PJ. Obesity: a challenge to esophagogastric junction integrity. Gastroenterology 2006; 130: 63949.
  • 35
    Hampel H, Abraham NS, El-Serag HB. Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications. Ann. Intern. Med. 2005; 143: 199211.